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. 1977 Jul;64(7):366-70.
doi: 10.1007/BF00368735.

[Biosynthesis and structure of the yeast fatty acid synthetase complex]

[Article in German]
E Schweizer

[Biosynthesis and structure of the yeast fatty acid synthetase complex]

[Article in German]
E Schweizer. Naturwissenschaften. 1977 Jul.

Abstract

Genetic as well as biochemical data suggest that the yeast fatty-acid synthetase complex has an (AB)6 protein structure where A and B represent multifunctional polypeptide chains with molecular weights of 185000 and 180000 daltons, respectively. Subunit A contains at least 3 and subunit B4 of the 8 known biochemical functions of the multienzyme complex. It is concluded that this complex structure has evolved from the corresponding prokaryotic system of monofunctional enzymes due to a selective advantage regarding the biosynthesis and assembly of the complex components.

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Cited by

  • Fatty acid biosynthesis in yeast.
    Schweizer E, Werkmeister K, Jain MK. Schweizer E, et al. Mol Cell Biochem. 1978 Nov 1;21(2):95-107. doi: 10.1007/BF00240280. Mol Cell Biochem. 1978. PMID: 31559 Review.

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