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Review
. 2021 Feb 26:11:629390.
doi: 10.3389/fonc.2021.629390. eCollection 2021.

Advances in CpG Island Methylator Phenotype Colorectal Cancer Therapies

Xiaofei Zhang  1 , Wenjun Zhang  2 , Pingan Cao  1
Affiliations
Review

Advances in CpG Island Methylator Phenotype Colorectal Cancer Therapies

Xiaofei Zhang et al. Front Oncol. .

Abstract

With the aging of the population, the incidence of colorectal cancer in China is increasing. One of the epigenetic alterations: CpG island methylator phenotype (CIMP) plays an important role in the incidence of colorectal cancer. Recent studies have shown that CIMP is closely related to some specific clinicopathological phenotypes and multiple molecular phenotypes in colorectal cancer. In this paper, the newest progress of CIMP colorectal cancer in chemotherapeutic drugs, targeted agents and small molecular methylation inhibitors are going to be introduced. We hope to provide potential clinical treatment strategies for personalized and precise treatment of colorectal cancer patients.

Keywords: CpG island methylator phenotype; DNA methylation inhibitor; chemotherapy; colorectal cancer; targeted therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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