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Review
. 2021 Feb 25:9:635719.
doi: 10.3389/fped.2021.635719. eCollection 2021.

Toward the Establishment of New Clinical Endpoints for Cystic Fibrosis: The Role of Lung Clearance Index and Cardiopulmonary Exercise Testing

Elpis Hatziagorou  1 , Asterios Kampouras  1 , Vasiliki Avramidou  1 , Ilektra Toulia  1 , Elisavet-Anna Chrysochoou  1 , Maria Galogavrou  1 , Fotios Kirvassilis  1 , John Tsanakas  1
Affiliations
Review

Toward the Establishment of New Clinical Endpoints for Cystic Fibrosis: The Role of Lung Clearance Index and Cardiopulmonary Exercise Testing

Elpis Hatziagorou et al. Front Pediatr. .

Abstract

As Cystic Fibrosis (CF) treatment advances, research evidence has highlighted the value and applicability of Lung Clearance Index and Cardiopulmonary Exercise Testing as endpoints for clinical trials. In the context of these new endpoints for CF trials, we have explored the use of these two test outcomes for routine CF care. In this review we have presented the use of these methods in assessing disease severity, disease progression, and the efficacy of new interventions with considerations for future research.

Keywords: cardiopulmonary exercise testing (CPET); cystic fibrosis; disease progression; disease severity; endpoints; lung clearance index (LCI).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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