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Review
. 2021 Feb 25:9:638559.
doi: 10.3389/fcell.2021.638559. eCollection 2021.

Critical Functions of PP2A-Like Protein Phosphotases in Regulating Meiotic Progression

Wen-Long Lei  1 , Wei-Ping Qian  1 , Qing-Yuan Sun  2
Affiliations
Review

Critical Functions of PP2A-Like Protein Phosphotases in Regulating Meiotic Progression

Wen-Long Lei et al. Front Cell Dev Biol. .

Abstract

Meiosis is essential to the continuity of life in sexually-reproducing organisms through the formation of haploid gametes. Unlike somatic cells, the germ cells undergo two successive rounds of meiotic divisions after a single cycle of DNA replication, resulting in the decrease in ploidy. In humans, errors in meiotic progression can cause infertility and birth defects. Post-translational modifications, such as phosphorylation, ubiquitylation and sumoylation have emerged as important regulatory events in meiosis. There are dynamic equilibrium of protein phosphorylation and protein dephosphorylation in meiotic cell cycle process, regulated by a conservative series of protein kinases and protein phosphatases. Among these protein phosphatases, PP2A, PP4, and PP6 constitute the PP2A-like subfamily within the serine/threonine protein phosphatase family. Herein, we review recent discoveries and explore the role of PP2A-like protein phosphatases during meiotic progression.

Keywords: PP2A; PP4; PP6; meiosis; protein phosphorylation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Role of PP2A-like protein phosphatases in meiotic progression.
See this image and copyright information in PMC

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