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. 2021 Feb;49(1):18-24.
doi: 10.5152/TJAR.2020.30. Epub 2020 Nov 30.

Comparison of the Effects of Low-flow and Normal-flow Desflurane Anaesthesia on Inflammatory Parameters in Patients Undergoing Laparoscopic Cholecystectomy

Tuğba Bingöl Tanrıverdi  1 , Mehmet Tercan  1 , Ayşe Güsun Halitoğlu  1 , Ahmet Kaya  1 , Gülçin Patmano  1
Affiliations

Comparison of the Effects of Low-flow and Normal-flow Desflurane Anaesthesia on Inflammatory Parameters in Patients Undergoing Laparoscopic Cholecystectomy

Tuğba Bingöl Tanrıverdi et al. Turk J Anaesthesiol Reanim. 2021 Feb.

Abstract

Objective: According to previous studies, anaesthesia type has an important effect on immune response. However, there are limited data determining the effect of low-flow and normal-flow desflurane anaesthesia on inflammatory parameters. This study aimed to investigate the effect of low-flow and normal-flow desflurane anaesthesia on inflammatory parameters in patients undergoing laparoscopic cholecystectomy.

Methods: A total of 92 patients who underwent laparoscopic cholecystectomy were retrospectively included in this study. The patients were divided into the following 2 groups according to the type of anaesthesia they received: low-flow desflurane anaesthesia group (fresh gas flow rate: 0.5 L min-1) and normal-flow desflurane anaesthesia group (fresh gas flow rate: 2 L min-1). Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were obtained before the procedure and 6 hours after the end of the procedure for all patients.

Results: Although pre-procedural NLR and PLR were similar between the normal-flow and low-flow anaesthesia groups, post-procedural NLR (4.38±2.00 vs. 3.51±1.37, p=0.023) and PLR (144.38±71.04 vs. 120.58±35.35, p=0.037) were significantly higher in the normal-flow anaesthesia group. In addition, compared with pre-procedural values, post-procedural NLR (from 2.31±1.02 to 4.38±2.00, p<0.001) and PLR (from 125.60±50.97 to 144.38±71.04, p=0.017) were significantly increased in the normal-flow anaesthesia group, whereas post-procedural NLR (from 2.88±2.51 to 3.51±1.37, p=0.135) and PLR (from 121.86±42.78 to 120.58±35.35, p=0.847) did not change significantly in the low-flow anaesthesia group.

Conclusion: The study results indicated that postoperative inflammatory response was significantly lower with low-flow desflurane anaesthesia than with normal-flow desflurane anaesthesia.

Keywords: Desflurane; inflammatory response; laparoscopic surgery; low-flow anaesthesia.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
a, b. Comparison of pre-procedural and post-procedural neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in normal-flow and low-flow anaesthesia groups
See this image and copyright information in PMC

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