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Review
. 2021 Jul;5(2):371-376.
doi: 10.1080/24725625.2021.1896096. Epub 2021 Mar 15.

IgG4-related disease presenting as a paraneoplastic syndrome: report of two cases and literature review

Mitsuteru Akahoshi  1 , Yojiro Arinobu  1 , Yusuke Kashiwado  1 , Aya Omoto  1 , Masahiro Ayano  1 , Hiroki Mitoma  1 , Yasutaka Kimoto  2 , Nobuyuki Ono  1 , Takahiko Horiuchi  2 , Hiroaki Niiro  3
Affiliations
Review

IgG4-related disease presenting as a paraneoplastic syndrome: report of two cases and literature review

Mitsuteru Akahoshi et al. Mod Rheumatol Case Rep. 2021 Jul.

Abstract

An association between immunoglobulin G4-related disease (IgG4-RD) and malignancy has been suggested. We report two cases of IgG4-RD with suspected paraneoplastic syndrome. In both patients, malignancy was observed immediately after diagnosis of IgG4-RD, and surgical resection resulted in spontaneous regression of IgG4-RD. We review the reports on IgG4-RD associated with malignancy, including these two cases, and discuss their relevance.

Keywords: IgG4-related disease; cancer; inflammatory carcinogenesis; malignancy; paraneoplastic syndrome.

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