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. 2022 Jan;21(1):331-336.
doi: 10.1111/jocd.14070. Epub 2021 Mar 26.

Role of vitamin D in treatment of keloid

Menna Mamdouh  1 , Ghada A Omar  1 , Hala S A Hafiz  1 , Sally M Ali  2
Affiliations

Role of vitamin D in treatment of keloid

Menna Mamdouh et al. J Cosmet Dermatol. 2022 Jan.

Abstract

Background: Keloid is a benign well-demarcated overgrowth of fibrotic tissue which extends beyond the original boundaries of a defect. The treatment of keloids is a particular challenge to dermatologists. Intralesional corticosteroid injection has been considered the first-line treatment for keloids. Vitamin D plays an important role in cell proliferation and differentiation as it slows the progression of tissue fibrosis by keloid fibroblasts and inhibits collagen synthesis in dermal fibrosis.

Objectives: To evaluate the efficacy of intralesional injection of vitamin D in the treatment of keloids, both clinically and ultrasonically.

Methods: Forty Egyptian patients with keloid scars were injected weekly with intralesional vitamin D with dose of 0.2 ml (200,000 IU) per 1 cm lesion. The keloid scars were evaluated with Vancouver Scar Scale (VSS) and by a high-resolution ultrasound using B mode before and after treatment, the patients received 3 to 4 sessions.

Results: There was statistically highly significant reduction in VSS after treatment with intralesional vitamin D injection (p value≤0.001). There was also statistically highly significant improvement in ultrasonic keloid scar thickness after treatment (P value ≤0.001).

Conclusions: Intralesional vitamin D is an effective and safe method in treatment of keloid scars. Ultrasound is a useful method in assessing the improvement of keloids after treatment.

Keywords: intralesional vitamin D3; keloid; ultrasound.

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References

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