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Meta-Analysis
. 2021 Mar 16;3(3):CD009231.
doi: 10.1002/14651858.CD009231.pub3.

Hospital at home: home-based end-of-life care

Sasha Shepperd  1 , Daniela C Gonçalves-Bradley  1 , Sharon E Straus  2 , Bee Wee  3
Affiliations
Meta-Analysis

Hospital at home: home-based end-of-life care

Sasha Shepperd et al. Cochrane Database Syst Rev. .

Abstract

Background: The policy several countries is to provide people with a terminal illness the choice of dying at home; this is supported by surveys that indicate that the general public and people with a terminal illness would prefer to receive end-of-life care at home. This is the fifth update of the original review.

Objectives: To determine if providing home-based end-of-life care reduces the likelihood of dying in hospital and what effect this has on patients' symptoms, quality of life, health service costs and caregivers compared with inpatient hospital or hospice care.

Search methods: We searched CENTRAL, Ovid MEDLINE(R), Embase, CINAHL, and clinical trials registries to 18 March 2020. We checked the reference lists of systematic reviews. For included studies, we checked the reference lists and performed a forward search using ISI Web of Science. We handsearched palliative care journals indexed by ISI Web of Science for online first references.

Selection criteria: Randomised controlled trials evaluating the effectiveness of home-based end-of-life care with inpatient hospital or hospice care for people aged 18 years and older.

Data collection and analysis: Two review authors independently extracted data and assessed study quality. When appropriate, we combined published data for dichotomous outcomes using a fixed-effect Mantel-Haenszel meta-analysis to calculate risk ratios (RR) with 95% confidence intervals (CI). When combining outcome data was not possible, we reported the results from individual studies.

Main results: We included four randomised trials and found no new studies from the search in March 2020. Home-based end-of-life care increased the likelihood of dying at home compared with usual care (RR 1.31, 95% CI 1.12 to 1.52; 2 trials, 539 participants; I2 = 25%; high-certainty evidence). Admission to hospital varied among the trials (range of RR 0.62, 95% CI 0.48 to 0.79, to RR 2.61, 95% CI 1.50 to 4.55). The effect on patient outcomes and control of symptoms was uncertain. Home-based end-of-life care may slightly improve patient satisfaction at one-month follow-up, with little or no difference at six-month follow-up (2 trials; low-certainty evidence). The effect on caregivers (2 trials; very low-certainty evidence), staff (1 trial; very low-certainty evidence) and health service costs was uncertain (2 trials, very low-certainty evidence).

Authors' conclusions: The evidence included in this review supports the use of home-based end-of-life care programmes for increasing the number of people who will die at home. Research that assesses the impact of home-based end-of-life care on caregivers and admissions to hospital would be a useful addition to the evidence base, and might inform the delivery of these services.

PubMed Disclaimer

Conflict of interest statement

SS: Co‐coordinating editor Cochrane EPOC

DGB: none.

SES: none.

BW is a full‐time salaried employee of the National Health Service in the UK. Her responsibilities include the provision of specialist palliative care services (in the hospice, community and hospital), service development, education and research in palliative care. Neither she, nor her organisation, stands to gain or lose from the conclusions of this review, but like other services within the National Health Service, the conclusions of this review may inform future service development or commissioning, or both.

Figures

1
1
Study flow diagram.
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
1.1
1.1. Analysis
Comparison 1: Place of death, Outcome 1: Dying at home
2.1
2.1. Analysis
Comparison 2: Unplanned admissions to hospital, Outcome 1: Admitted to hospital
See this image and copyright information in PMC

Update of

References

References to studies included in this review

Brumley 2007 {published data only}
    1. Brumley R, Enguidanot S, Jamison P, Seitz R, Morgenstern N, Saito S, et al. Increased satisfaction with care and lower costs: results of a randomized trial of in-home palliative care. Journal of the American Geriatrics Society 2007;S5:993-1000. - PubMed
Grande 1999 {published data only}
    1. Grande G, Farquhar MC, Barclay SI. Caregiver bereavement outcome: relationship with hospital at home, satisfaction with care and home death. Journal of Palliative Care 2004;20(2):69-77. - PubMed
    1. Grande GE, Todd CJ, Barclay SI, Farquhar MC. A randomised controlled trial of a hospital at home service for the terminally ill. Palliative Medicine 2000;14:375-85. - PubMed
    1. Grande GE, Todd CJ, Barclay SI, Farquhar MC. Does hospital at home for palliative care facilitate death at home? Randomised controlled trial. BMJ 1999;319:1472-5. - PMC - PubMed
Hughes 1992 {published data only}
    1. Hughes SL, Cummings J, Weaver F, Manheim L, Braun B, Conrad K. A randomized trial of the cost effectiveness of VA hospital-based home care for the terminally ill. Health Services Research 1992;26:801-17. - PMC - PubMed
Jordhøy 2000 {published data only}
    1. Jordhøy MS, Fayers P, Saltnes T, Ahlner-Elmqvist M, Jannert M, Kaasa S. A palliative care intervention and death at home: a cluster randomized trial. Lancet 2000;356:888-93. - PubMed

References to studies excluded from this review

Brännström 2014 {published data only}
    1. Brännström M, Boman K. Effects of person-centred and integrated chronic heart failure and palliative home care. PREFER: a randomized controlled study. European Journal of Heart Failure 2014;16(10):1142-51. - PubMed
Brumley 2003 {published data only}
    1. Brumley RD, Enguidanos S, Cherin DA. Effectiveness of a home-based palliative care program for end-of-life. Journal of Palliative Medicine 2003;6(5):715-24. - PubMed
Enguidanos 2005 {published data only}
    1. Enguidanos SM, Cherin D, Brumley R. Home-based palliative care study: site of death, and costs of medical care for patients with congestive heart failure, chronic obstructive pulmonary disease, and cancer. Journal of Social Work in End-of-life & Palliative Care 2005;1(3):37-56. - PubMed
Enguidanos 2019 {published data only}
    1. Enguidanos S, Fields T, Brumley R. Home-based palliative care: translating a research model into a primary care benefit. Journal of Pain and Symptom Management 2016;51(2):369-70.
    1. Enguidanos S, Fields T. Barriers and challenges to implementing a palliative care comparative effectiveness trial in the US. Palliative Medicine 2018;32(1):208-9.
    1. Enguidanos S, Rahman A, Fields T, Mack W, Brumley R, Rabow M, et al. Expanding access to home-based palliative care: a randomized controlled trial protocol. Journal of Palliative Medicine 2019;22(S1):S58-S65. - PubMed
Holdsworth 2015 {published data only}
    1. Holdsworth LM, Gage H, Coulton S, King A, Butler C. A quasi-experimental controlled evaluation of the impact of a hospice rapid response community service for end-of-life care on achievement of preferred place of death. Palliative Medicine 2015;29(9):817-25. [DOI: 10.1177/0269216315582124] - DOI - PubMed
Hughes 1990 {published data only}
    1. Hughes SL, Cummings J, Weaver F, Manheim LM, Conrad KJ, Nash K. A randomized trial of Veterans Administration home care for severely disabled veterans. Medical Care 1990;28(2):135-45. - PubMed
Hughes 2000 {published data only}
    1. Hughes SL, Weaver FM, Giobbie-Hurder A, Manheim L, Henderson W, Kubal JD, et al, Department of Veterans Affairs Cooperative Study Group on Home-Based Primary Care. Effectiveness of team-managed home-based primary care: a randomized multicenter trial. JAMA 2000;284(22):2877-85. - PubMed
Markgren 2019 {published data only}
    1. Markgren R, Brannstrom M, Lundgren C, Boman K. Impacts of person-centred integrated chronic heart failure and palliative home care on pharmacological heart failure treatment: a substudy of a randomised trial. BMJ Supportive & Palliative Care 2019;9(1):e10. [DOI: 10.1136/bmjspcare-2015-000894] - DOI - PubMed
McCaffrey 2013 {published data only}
    1. McCaffrey N, Agar M, Harlum J, Karnon J, Currow D, Eckermann S. Better informing decision making with multiple outcomes cost-effectiveness analysis under uncertainty in cost-disutility space. PloS One 2015;10(3):e0115544. [DOI: 10.1371/journal.pone.0115544] - DOI - PMC - PubMed
    1. McCaffrey N, Agar M, Harlum J, Karnon J, Currow D, Eckermann S. Is home-based palliative care cost-effective? An economic evaluation of the Palliative Care Extended Packages at Home (PEACH) pilot. BMJ Supportive & Palliative Care 2013;3(4):431-5. [DOI: 10.1136/bmjspcare-2012-000361] - DOI - PubMed
McCusker 1987 {published data only}
    1. McCusker J, Stoddard AM. Effects of an expanding home care program for the terminally ill. Medical Care 1987;25:373-85. - PubMed
McWhinney 1994 {published data only}
    1. McWhinney IR, Bass MJ, Donner A. Evaluation of a palliative care service: problems and pitfalls. BMJ 1994;309:1340-2. - PMC - PubMed
NCT01885637 {published data only}
    1. NCT01885637. DOMUS: a trial of accelerated transition from oncological treatment to continuing palliative care at home. clinicaltrials.gov/ct2/show/NCT01885637 (first received 25 June 2013).
    1. Nordly M, Benthien KS, Maase H, Johansen C, Kruse M, Timm H, et al. The DOMUS study protocol: a randomized clinical trial of accelerated transition from oncological treatment to specialized palliative care at home. BMC Palliative Care 2014;13:44. - PMC - PubMed
Ng 2018 {published data only}
    1. Ng AY, Wong FK, Lee PH. Effects of a transitional palliative care model on patients with end-stage heart failure: study protocol for a randomized controlled trial. Trials 2016;17:173. [DOI: 10.1186/s13063-016-1303-7] - DOI - PMC - PubMed
    1. Ng AY, Wong FK. Effects of a home-based palliative heart failure program on quality of life, symptom burden, satisfaction and caregiver burden: a randomized controlled trial. Journal of Pain and Symptom Management 2018;55(1):1-11. [DOI: 10.1016/j.jpainsymman.2017.07.047] - DOI - PubMed
NTR2817 {published data only}
    1. Duursma F, Schers HJ, Vissers KC, Hasselaar J. Study protocol: optimization of complex palliative care at home via telemedicine. A cluster randomized controlled trial. BMC Palliative Care 2011;10:13. - PMC - PubMed
    1. NTR2817. Optimization of complex palliative care at home by means of expert consultation via telemedicine. www.trialregister.nl/trial/2688 (first received 21 March 2011).
Scheerens 2020 {published data only}
    1. Scheerens C, Pype P, Cauwenberg J, Vanbutsele G, Eecloo K, Derom E, et al. Early integrated palliative home care and standard care for end-stage COPD (EPIC): a phase II pilot RCT testing feasibility, acceptability, and effectiveness. Journal of Pain and Symptom Management 2020;59(2):206-224.e7. [DOI: 10.1016/j.jpainsymman.2019.09.012] - DOI - PubMed
Stern 2006 {published data only}
    1. Stern A, Goldsmith C, Thabane L, Abernathy T, Cohen R, Jadad A, et al. The efficacy of home telehealth in palliative care for oncology patients and their caregivers. Journal of Palliative Care 2006;22:208-9.
Zimmerman 2014 {published data only}
    1. Mohammed S, Swami N, Pope A, Hannon B, Zimmerman C. Managing the bureaucracy of dying: a qualitative study of lay caregivers as care coordinators for cancer patients dying in the home. Psycho-oncology 2015;24:83-4.
    1. Mohammed S, Swami N, Pope A, Rodin G, Hannon B, Hales S, et al. Family caregivers' experience of providing end of life homecare in advanced cancer: a grounded theory study. Palliative Medicine 2016;30(6):NP147.
    1. Mohammed S, Swami N, Pope A, Rodin G, Hannon B, Nissim R, et al. "I didn't want to be in charge and yet I was": bereaved caregivers' accounts of providing home care for family members with advanced cancer. Psycho-Oncology 2018;27(4):1229-36. [DOI: 10.1002/pon.4657] - DOI - PubMed
    1. Zimmerman C, Swami N, Kryzanowska M, Hannon B, Leighl N, Oza A, et al. Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial. Lancet 2014;383(9930):1721-30. [DOI: 10.1016/S0140-6736(13)62416-2] - DOI - PubMed

References to ongoing studies

NCT03793803 {published data only}
    1. NCT03793803. Trial of Mount Sinai palliative care at home. clinicaltrials.gov/ct2/show/NCT03793803 (first received 4 January 2019).
NCT03798327 {published data only}
    1. NCT03798327. Mount Sinai palliative care at home for dementia. clinicaltrials.gov/ct2/show/NCT03798327 (first received 9 January 2019).
NCT04048590 {published data only}
    1. NCT04048590. Skilled nursing facility at home: a pilot. clinicaltrials.gov/ct2/show/NCT04048590 (first received 7 August 2019).
NCT04243538 {published data only}
    1. NCT04243538. Developing and piloting a multi-component technology-based care intervention to address patient symptoms and caregiver burden in home hospice. clinicaltrials.gov/ct2/show/NCT04243538 (first received 28 January 2020).

Additional references

Agelopoulos 2009
    1. Agelopoulos N, Tate T. The Marie Curie Delivering Choice Programme. European Journal of Palliative Care 2009;16:290-4.
Ali 2019
    1. Ali M, Capel M, Jones G, Gazi T. The importance of identifying preferred place of death. BMJ Supportive & Palliative Care 2019;9(1):84-91. - PubMed
Arnold 2015
    1. Arnold E, Finucane AM, Oxenham D. Preferred place of death for patients referred to a specialist palliative care service. BMJ Supportive & Palliative Care 2015;5(3):294-6. - PMC - PubMed
Bainbridge 2016
    1. Bainbridge D, Seow H, Sussman J. Common components of efficacious in-home end-of-life care programs: a review of systematic reviews. Journal of the American Geriatrics Society 2016;64(3):632-9. - PubMed
Bradburn 2007
    1. Bradburn MJ, Deeks JJ, Berlin JA, Russell Localio A. Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events. Statistics in Medicine 2007;26(1):53-77. - PubMed
Choice in End of Life Care 2015
    1. Choice in End of Life Care Programme Board. What’s important to me. A review of choice in end of life care. assets.publishing.service.gov.uk/government/uploads/system/uploads/attac... (accessed 14 October 2020).
Cochrane 1954
    1. Cochrane WG. The combination of estimates from different experiments. Biometrics 1954;10:101-29.
Cohen 2017
    1. Cohen J, Beernaert K, Van den Block L, Morin L, Hunt K, Miccinesi G, et al. Differences in place of death between lung cancer and COPD patients: a 14-country study using death certificate data. Primary Care Respiratory Journal 2017;27:14. [DOI: 10.1038/s41533-017-0017-y] - DOI - PMC - PubMed
Decker 2006
    1. Decker SL, Higginson IJ. A tale of two cities: factors affecting place of cancer death in London and New York. European Journal of Public Health 2006;17(3):285-90. - PubMed
ELCC 2016
    1. The End of Life Care Coalition. On the brink: the future of end of life care. endoflifecampaign.org/wp-content/uploads/2016/02/End-of-Life-Report-WEB.pdf (accessed 17 November 2020).
EPOC 2010
    1. Cochrane Effective Practice and Organisation of Care Review Group. Data abstraction form. www.epoc.uottawa.ca/tools.htm (accessed June 2010).
Gomes 2008
    1. Gomes B, Higginson IJ. Where people die (1974 to 2030): past trends, future projections and implications for care. Palliative Medicine 2008;22:33-41. - PubMed
Gomes 2012
    1. Gomes B, Higginson IJ, Calanzani N, Cohen J, Deliens L, Daveson BA, et al, PRISMA. Preferences for place of death if faced with advanced cancer: a population survey in England, Flanders, Germany, Italy, the Netherlands, Portugal and Spain. Annals of Oncology 2012;238(8):2006-15. - PubMed
Gonçalves‐Bradley 2017
    1. Gonçalves-Bradley DC, Iliffe S, Doll HA, Broad J, Gladman J, Langhorne P. Hospital at home early discharge. Cochrane Database of Systematic Reviews 2017, Issue 6. Art. No: CD000356. [DOI: 10.1002/14651858.CD000356.pub4] - DOI - PMC - PubMed
Gott 2004
    1. Gott M, Seymour J, Bellamy G, Clark D, Ahmedzai S. Older people's views about home as a place of care at the end of life. Palliative Medicine 2004;18:460-7. - PubMed
Grande 2004
    1. Grande G, Farquhar MC, Barclay SI. Caregiver bereavement outcome: relationship with hospital at home, satisfaction with care and home death. Journal of Palliative Care 2004;20(2):69-77. - PubMed
Guyatt 2008
    1. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al, GRADE Working Group. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008;336(7650):924-6. [DOI: 10.1136/bmj.39489.470347.AD] - DOI - PMC - PubMed
Harrold 2014
    1. Harrold J, Byhoff E, Harris P, Szolarova R, Bender L, Craig T, et al. All hospice patients are not equal: development of a visit-based acuity index. Journal of Palliative Medicine 2014;17(2):135-40. - PubMed
Higgins 2003
    1. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analysis. BMJ 2003;327:557-60. - PMC - PubMed
Higgins 2011
    1. Higgins JP, Altman DG, Sterne JA. Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from training.cochrane.org/handbook/archive/v5.1/. [DOI: 10.1002/9780470712184.ch8] - DOI
Higginson 2000
    1. Higginson IJ, Sen-Gupta GJ. Place of care in advanced cancer: a qualitative systematic literature review of patient preferences. Journal of Palliative Medicine 2000;3(3):287-300. - PubMed
Higginson 2013
    1. Higginson IJ, Evans CJ, Grande G, Preston N, Morgan M, McCrone P, et al, on behalf of MORECare. Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews. BMC Medicine 2013;11:111. - PMC - PubMed
Kleinman 2009
    1. Kleinman A. Caregiving: the odyssey of becoming more human. Lancet 2009;373:292-3. - PubMed
Koyama 2020
    1. Koyama T, Hagiya H, Funahashi T, Zamami Y, Yamagishi M, Onoue H, et al. Trends in place of death in a super-aged society: a population-based study, 1998–2017. Journal of Palliative Medicine 2020;23(7):950-6. [DOI: 10.1089/jpm.2019.0445] - DOI - PubMed
Luckett 2013
    1. Luckett T, Davidson PM, Lam L, Phillips J, Currow DC, Agar M. Do community specialist palliative care services that provide home nursing increase rates of home death for people with life-limiting illnesses? A systematic review and meta-analysis of comparative studies. Journal of Pain and Symptom Management 2013;45(2):279-97. - PubMed
Masella 2015
    1. Masella C, Garavaglia G, Borghi G, Castelli A, Radaelli G, Peruselli C. Implementation of a hospital-based home palliative care at regional level: a quantitative study of the Ospedalizzazione Domiciliare Cure Palliative Oncologiche program in Lombardy. Palliative Medicine 2015;29(3):241-8. - PubMed
MECIR 2020
    1. Higgins J, Lasserson T, Chandler J, Tovey D, Thomas J, Flemyng E, et al. Standards for the conduct and reporting of new Cochrane Intervention Reviews, reporting of protocols and the planning, conduct and reporting of updates. community.cochrane.org/mecir-manual (accessed 14 October 2020).
Miranda 2019
    1. Miranda R, Bunn F, Lynch J, den Block L, Goodman C. Palliative care for people with dementia living at home: a systematic review of interventions. Palliative Medicine 2019;33(7):726-42. - PMC - PubMed
National Audit Office 2008
    1. National Audit Office. End of life care. www.nao.org.uk/wp-content/uploads/2008/11/07081043.pdf (accessed 5 February 2016).
NEoLCIN 2014
    1. National End of Life Care Intelligence Network. What We Know Now 2014. London: Public Health England, 2014.
NHS England 2014
    1. NHS England. Actions for end of life care: 2014–16. www.england.nhs.uk/wp-content/uploads/2014/11/actions-eolc.pdf (accessed 14 October 2020).
NICE 2019
    1. Developed by the National Guideline Centre. End of life care for adults: service delivery, 2019. www.nice.org.uk/guidance/ng142/evidence/c-barriers-to-accessing-end-of-l... (accessed prior to 26 February 2021).
Noble 2015
    1. Noble B, King N, Woolmore A, Hughes P, Winslow M, Melvin J, et al. Can comprehensive specialised end-of-life care be provided at home? Lessons from a study of an innovative consultant-led community service in the UK. European Journal of Cancer Care 2015;24(2):253-66. - PMC - PubMed
Review Manager 2014 [Computer program]
    1. Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan). Version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
Seamark 2014
    1. Seamark D, Blake S, Brearley SG, Milligan C, Thomas C2, Turner M, et al. Dying at home: a qualitative study of family carers' views of support provided by GPs community staff. British Journal of General Practice 2014;64(629):e-796-803. - PMC - PubMed
Shepperd 2016a
    1. Shepperd S, Doll H, Angus R, Clarke M, Iliffe S, Kalra L, et al. Hospital at home admission avoidance. Cochrane Database of Systematic Reviews 2016, Issue 9. Art. No: CD007491. [DOI: 10.1002/14651858.CD007491.pub2] - DOI - PMC - PubMed
Smeenk 1998
    1. Smeenk FW, Haastregt JC, Witte LP, Crebolder HF. Effectiveness of home care programmes for patients with incurable cancer on their quality of life and time spent in hospital: a systematic review. BMJ 1998;316:1939-44. - PMC - PubMed
Tang 2010
    1. Tang ST, Huang EW, Liu TW, Rau KM, Hung YN, Wu SC. Propensity for home death among Taiwanese cancer decedents in 2001-2006, determined by services received at end of life. Journal of Pain and Symptom Management 2010;40(4):566-74. [DOI: 10.1016/j.jpainsymman.2010.01.020] - DOI - PubMed
Wilson 2009
    1. Wilson DM, Truman CD, Thomas R, Fainsinger R, Kovacs-Burns K, Froggatt K, et al. The rapidly changing location of death in Canada, 1994–2004. Social Science & Medicine 2009;68(10):1752-8. - PubMed
Woodman 2016
    1. Woodman C, Baillie J, Sivvel S. The preferences and perspectives of family caregivers towards place of care for their relatives at the end-of-life. A systematic review and thematic synthesis of the qualitative evidence. BMJ Supportive & Palliative Care 2016;6(4):418-29. [DOI: 10.1136/bmjspcare-2014-000794] - DOI - PMC - PubMed
Zimmermann 2008
    1. Zimmermann C, Riechelmann R, Kryzanowska M, Rodin G, Tannock I. Effectiveness of specialised palliative care – a systematic review. JAMA 2008;299(14):1698-709. - PubMed

References to other published versions of this review

Shepperd 2005
    1. Shepperd S, Iliffe S. Hospital at home versus in-patient hospital care. Cochrane Database of Systematic Reviews 2005, Issue 3. Art. No: CD000356. [DOI: 10.1002/14651858.CD000356.pub2] - DOI - PubMed
Shepperd 2011
    1. Shepperd S, Wee B, Straus SE. Hospital at home: home-based end of life care. Cochrane Database of Systematic Reviews 2011, Issue 7. Art. No: CD009231. [DOI: 10.1002/14651858.CD009231] - DOI - PMC - PubMed
Shepperd 2016b
    1. Shepperd S, Gonçalves-Bradley DC, Straus SE, Wee B. Hospital at home: home‐based end‐of‐life care. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No: CD009231. [DOI: 10.1002/14651858.CD009231] - DOI - PMC - PubMed

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