Mutations in the HIV-1 3'-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance

doi:10.1128/AAC.02432-20

. 2021 May 18;65(6):e02432-20.

doi: 10.1128/AAC.02432-20. Print 2021 May 18.

Mutations in the HIV-1 3'-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance

Yuliang Wei^{1

2}, Nicolas Sluis-Cremer³

Affiliations

¹ Tsinghua MD Program, School of Medicine, Tsinghua University, Beijing, China.
² Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
³ Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA nps2@pitt.edu.

PMID: 33722887
PMCID: PMC8316055
DOI: 10.1128/AAC.02432-20

Mutations in the HIV-1 3'-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance

Yuliang Wei et al. Antimicrob Agents Chemother. 2021.

. 2021 May 18;65(6):e02432-20.

doi: 10.1128/AAC.02432-20. Print 2021 May 18.

Authors

Yuliang Wei^{1

2}, Nicolas Sluis-Cremer³

Affiliations

¹ Tsinghua MD Program, School of Medicine, Tsinghua University, Beijing, China.
² Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
³ Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA nps2@pitt.edu.

PMID: 33722887
PMCID: PMC8316055
DOI: 10.1128/AAC.02432-20

No abstract available

Keywords: HIV; integrase; polypurine tract; resistance.

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Figures

**FIG 1**
Replication capacity of HIV-1^WT, HIV-1^PPT(1), and HIV-1^PPT(2). TZM-bl cells were infected with 27 ng p24 (A) or 81 ng p24 (B) of each virus. A single-copy assay for extracellular virion-associated HIV-1 RNA was used to quantify virus production, as described previously (9). Data are reported as the average of two independent experiments.

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Different Pathways Conferring Integrase Strand-Transfer Inhibitors Resistance.
Richetta C, Tu NQ, Delelis O. Richetta C, et al. Viruses. 2022 Nov 22;14(12):2591. doi: 10.3390/v14122591. Viruses. 2022. PMID: 36560595 Free PMC article. Review.
Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration.
Richetta C, Subra F, Malet I, Leh H, Charpentier C, Corona A, Collin G, Descamps D, Deprez E, Parissi V, Calvez V, Tramontano E, Marcelin AG, Delelis O. Richetta C, et al. J Virol. 2022 Jul 27;96(14):e0067622. doi: 10.1128/jvi.00676-22. Epub 2022 Jun 27. J Virol. 2022. PMID: 35758669 Free PMC article.
Specific mutations in the HIV-1 G-tract of the 3'-polypurine tract cause resistance to integrase strand transfer inhibitors.
Hachiya A, Kubota M, Shigemi U, Ode H, Yokomaku Y, Kirby KA, Sarafianos SG, Iwatani Y. Hachiya A, et al. J Antimicrob Chemother. 2022 Feb 23;77(3):574-577. doi: 10.1093/jac/dkab448. J Antimicrob Chemother. 2022. PMID: 34894227 Free PMC article.
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Li F, Lee M, Esnault C, Wendover K, Guo Y, Atkins P, Zaratiegui M, Levin HL. Li F, et al. Sci Adv. 2022 Jul;8(26):eabm9390. doi: 10.1126/sciadv.abm9390. Epub 2022 Jun 29. Sci Adv. 2022. PMID: 35767609 Free PMC article.

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References

1. Anstett K, Brenner B, Mesplede T, Wainberg MA. 2017. HIV drug resistance against strand transfer integrase inhibitors. Retrovirology 14:36. doi:10.1186/s12977-017-0360-7. - DOI - PMC - PubMed
1. Malet I, Subra F, Charpentier C, Collin G, Descamps D, Calvez V, Marcelin AG, Delelis O. 2017. Mutations located outside the integrase gene can confer resistance to HIV-1 integrase strand transfer inhibitors. mBio 8:e00922-17. doi:10.1128/mBio.00922-17. - DOI - PMC - PubMed
1. Wijting I, Lungu C, Rijnders B, van der Ende ME, Pham HT, Mesplede T, Pas SD, Voermans J, Schuurman R, van de Vijver D, Boers P, Gruters RA, Boucher C, van Kampen J. 2018. HIV-1 resistance dynamics in patients with virologic failure to dolutegravir maintenance monotherapy. J Infect Dis 218:688–697. doi:10.1093/infdis/jiy176. - DOI - PubMed
1. Giacobbi NS, Sluis-Cremer N. 2017. In vitro cross-resistance profiles of rilpivirine, dapivirine, and MIV-150, nonnucleoside reverse transcriptase inhibitor microbicides in clinical development for the prevention of HIV-1 infection. Antimicrob Agents Chemother 61:e00277-17. doi:10.1128/AAC.00277-17. - DOI - PMC - PubMed
1. Grobler JA, Dornadula G, Rice MR, Simcoe AL, Hazuda DJ, Miller MD. 2007. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem 282:8005–8010. doi:10.1074/jbc.M608274200. - DOI - PubMed

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[1] Anstett K, Brenner B, Mesplede T, Wainberg MA. 2017. HIV drug resistance against strand transfer integrase inhibitors. Retrovirology 14:36. doi:10.1186/s12977-017-0360-7. - DOI - PMC - PubMed

[2] Anstett K, Brenner B, Mesplede T, Wainberg MA. 2017. HIV drug resistance against strand transfer integrase inhibitors. Retrovirology 14:36. doi:10.1186/s12977-017-0360-7. - DOI - PMC - PubMed

[3] Malet I, Subra F, Charpentier C, Collin G, Descamps D, Calvez V, Marcelin AG, Delelis O. 2017. Mutations located outside the integrase gene can confer resistance to HIV-1 integrase strand transfer inhibitors. mBio 8:e00922-17. doi:10.1128/mBio.00922-17. - DOI - PMC - PubMed

[4] Malet I, Subra F, Charpentier C, Collin G, Descamps D, Calvez V, Marcelin AG, Delelis O. 2017. Mutations located outside the integrase gene can confer resistance to HIV-1 integrase strand transfer inhibitors. mBio 8:e00922-17. doi:10.1128/mBio.00922-17. - DOI - PMC - PubMed

[5] Wijting I, Lungu C, Rijnders B, van der Ende ME, Pham HT, Mesplede T, Pas SD, Voermans J, Schuurman R, van de Vijver D, Boers P, Gruters RA, Boucher C, van Kampen J. 2018. HIV-1 resistance dynamics in patients with virologic failure to dolutegravir maintenance monotherapy. J Infect Dis 218:688–697. doi:10.1093/infdis/jiy176. - DOI - PubMed

[6] Wijting I, Lungu C, Rijnders B, van der Ende ME, Pham HT, Mesplede T, Pas SD, Voermans J, Schuurman R, van de Vijver D, Boers P, Gruters RA, Boucher C, van Kampen J. 2018. HIV-1 resistance dynamics in patients with virologic failure to dolutegravir maintenance monotherapy. J Infect Dis 218:688–697. doi:10.1093/infdis/jiy176. - DOI - PubMed

[7] Giacobbi NS, Sluis-Cremer N. 2017. In vitro cross-resistance profiles of rilpivirine, dapivirine, and MIV-150, nonnucleoside reverse transcriptase inhibitor microbicides in clinical development for the prevention of HIV-1 infection. Antimicrob Agents Chemother 61:e00277-17. doi:10.1128/AAC.00277-17. - DOI - PMC - PubMed

[8] Giacobbi NS, Sluis-Cremer N. 2017. In vitro cross-resistance profiles of rilpivirine, dapivirine, and MIV-150, nonnucleoside reverse transcriptase inhibitor microbicides in clinical development for the prevention of HIV-1 infection. Antimicrob Agents Chemother 61:e00277-17. doi:10.1128/AAC.00277-17. - DOI - PMC - PubMed

[9] Grobler JA, Dornadula G, Rice MR, Simcoe AL, Hazuda DJ, Miller MD. 2007. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem 282:8005–8010. doi:10.1074/jbc.M608274200. - DOI - PubMed

[10] Grobler JA, Dornadula G, Rice MR, Simcoe AL, Hazuda DJ, Miller MD. 2007. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem 282:8005–8010. doi:10.1074/jbc.M608274200. - DOI - PubMed

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Mutations in the HIV-1 3'-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance

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Mutations in the HIV-1 3'-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance

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