Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Apr 5;118(14):e2102057118.
doi: 10.1073/pnas.2102057118.

Metabolic plasticity allows cancer cells to thrive under nutrient starvation

Wilhelm Palm  1
Affiliations
Comment

Metabolic plasticity allows cancer cells to thrive under nutrient starvation

Wilhelm Palm. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no competing interest.

Figures

Fig. 1.
Fig. 1.
Investigating metabolic plasticity in pancreatic cancer cells. Several human PDA cell lines were cultured in starvation media (0.5 mM glucose [gluc]/0.1 mM glutamine [gln]) for several weeks. From the surviving cells, several clonal lines were established. Starvation-adapted clones could proliferate in glucose/glutamine-deprived media and displayed increased tumor formation in mice. Adapted clones further displayed consistent molecular alterations, including increased mTORC1 activity, glutamine synthesis, and chromatin accessibility. These changes were reversible and gradually lost when starvation-adapted clones were reverted to full media.
See this image and copyright information in PMC

Comment on

References

    1. Pavlova N. N., Thompson C. B., The emerging hallmarks of cancer metabolism. Cell Metab. 23, 27–47 (2016). - PMC - PubMed
    1. Tsai P.-Y.et al. ., Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc. Natl. Acad. Sci. U.S.A. 118, e2003014118 (2021). - PMC - PubMed
    1. Vander Heiden M. G., Cantley L. C., Thompson C. B., Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324, 1029–1033 (2009). - PMC - PubMed
    1. Palm W., Thompson C. B., Nutrient acquisition strategies of mammalian cells. Nature 546, 234–242 (2017). - PMC - PubMed
    1. Mayers J. R., et al. ., Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science 353, 1161–1165 (2016). - PMC - PubMed

LinkOut - more resources