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Comment
. 2021 May;61(5):1654-1656.
doi: 10.1111/trf.16381. Epub 2021 Mar 26.

COVID-19 convalescent plasma; time for "goal directed therapy"?

Charles Michael Knudson  1 , J Brooks Jackson  1
Affiliations
Comment

COVID-19 convalescent plasma; time for "goal directed therapy"?

Charles Michael Knudson et al. Transfusion. 2021 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest relevant to this manuscript submitted to TRANSFUSION.

Comment on

  • Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19.
    Joyner MJ, Carter RE, Senefeld JW, Klassen SA, Mills JR, Johnson PW, Theel ES, Wiggins CC, Bruno KA, Klompas AM, Lesser ER, Kunze KL, Sexton MA, Diaz Soto JC, Baker SE, Shepherd JRA, van Helmond N, Verdun NC, Marks P, van Buskirk CM, Winters JL, Stubbs JR, Rea RF, Hodge DO, Herasevich V, Whelan ER, Clayburn AJ, Larson KF, Ripoll JG, Andersen KJ, Buras MR, Vogt MNP, Dennis JJ, Regimbal RJ, Bauer PR, Blair JE, Paneth NS, Fairweather D, Wright RS, Casadevall A. Joyner MJ, et al. N Engl J Med. 2021 Mar 18;384(11):1015-1027. doi: 10.1056/NEJMoa2031893. Epub 2021 Jan 13. N Engl J Med. 2021. PMID: 33523609 Free PMC article.

References

    1. Wenjing L, Yuanzheng F, Li JY, Tang LV, Yu H. Safety and efficacy of convalescent plasma therapy in severely and critically ill patients with COVID‐19: A systematic review with meta‐analysis. Aging (Albany NY). 2020;12:1498–509. - PMC - PubMed
    1. Meher BR, Padhy BM, Das S, Mohanty RR, Agrawal K. Effectiveness of convalescent plasma therapy in the treatment of moderate to severe COVID 19 patients: A systematic review and meta‐analysis. J Assoc Physicians India. 2020;68:35–43. - PubMed
    1. Sun M, Xu Y, He H, Zhang L, Wang X, Qiu Q, et al. Potential effective treatment for COVID‐19: Systematic review and meta‐analysis of the severe infectious disease with convalescent plasma therapy. Int J Infect Dis. 2020;98:334–46. - PMC - PubMed
    1. Libster R, Pérez Marc G, Wappner D, Coviello S, Bianchi A, Braem V, et al. Early high‐titer plasma therapy to prevent severe Covid‐19 in older adults. N Engl J Med. 2021;384: 610–8. - PMC - PubMed
    1. Knudson CM, Jackson JB. COVID‐19 convalescent plasma: Phase 2. Transfusion. 2020;60:1332–3. - PMC - PubMed