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. 2021 May 27;36(6):1135-1138.
doi: 10.1093/ndt/gfab067.

Prevalence and outcomes of hyponatremia and hypernatremia in patients hospitalized with COVID-19

Jamie S Hirsch  1   2   3 , Nupur N Uppal  1 , Purva Sharma  1 , Yuriy Khanin  1 , Hitesh H Shah  1 , Deepa A Malieckal  1 , Alessandro Bellucci  1 , Mala Sachdeva  1 , Helbert Rondon-Berrios  4 , Kenar D Jhaveri  1 , Steven Fishbane  1 , Jia H Ng  1 ; Northwell Nephrology COVID-19 Research Consortium
Collaborators, Affiliations

Prevalence and outcomes of hyponatremia and hypernatremia in patients hospitalized with COVID-19

Jamie S Hirsch et al. Nephrol Dial Transplant. .
No abstract available

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Figures

FIGURE 1
FIGURE 1
Mortality by admission serum sodium category, stratified by decile of age. The proportion of patients who experienced in-hospital death was highest among those with hypernatremia. Patients with hyponatremia also had a higher proportion of death as compared with normonatremia across age deciles, with the exception of patients ≥80 years old, where hyponatremia and normonatremia had similar proportions of in-hospital death.
FIGURE 2
FIGURE 2
The association of serum sodium at hospital presentation and mortality demonstrated a U-shaped pattern. Both hyponatremia and hypernatremia were significantly associated with mortality, which was more pronounced at the extremes of serum sodium, even after adjustment for demographic, comorbid conditions and illness severity (A). Following correction of serum sodium for serum glucose using the Katz (B) and Hillier (C) formulas, serum sodium levels in the hypernatremic range remained significantly associated with in-hospital death, but levels in the hyponatremic range were no longer associated with mortality. A serum sodium value of 140 mEq/L was used as the reference value.
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