Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb;170(4):431-435.
doi: 10.1007/s10517-021-05081-y. Epub 2021 Mar 16.

Does the Operation of Mitochondrial ATP-Dependent Potassium Channels Affect the Structural Component of Mitochondrial and Endothelial Dysfunctions in Experimental Parkinsonism?

A A Mosentsov  1 , E V Rozova  2 , N V Belosludtseva  1 , I N Mankovskaya  2 , Yu V Putiy  2 , I N Karaban  3 , I B Mikheeva  1 , G D Mironova  4
Affiliations

Does the Operation of Mitochondrial ATP-Dependent Potassium Channels Affect the Structural Component of Mitochondrial and Endothelial Dysfunctions in Experimental Parkinsonism?

A A Mosentsov et al. Bull Exp Biol Med. 2021 Feb.

Abstract

We have previously demonstrated that the development of oxidative stress in some pathologies can be prevented by activation of the mitochondrial ATP-dependent potassium channel (mitoKATP). Here we studied the effect of modulation of mitoKATP on the development of mitochondrial and endothelial dysfunction in the medulla oblongata and myocardium of rats with experimental parkinsonism. It is known that uridine-5'-diphosphate, activator of mitoKATP, does not penetrate the plasma membrane, but it can be synthesized in cells from exogenous uridine that is delivered into cells by special transport systems. Our results suggest that mitoKATP is involved in the development of mitochondrial and endothelial dysfunction in experimental parkinsonism and prove the cardio- and neuroprotective effects of uridine.

Keywords: mitochondria; mitochondrial ATP-dependent potassium channel; parkinsonism; rotenone; uridine.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Krylova IB, Bulion VV, Selina EN, Mironova GD, Sapronov NS. Effect of uridine on energy metabolism, LPO, and antioxidant system in the myocardium under conditions of acute coronary insufficiency. Bull. Exp. Biol. Med. 2012;153(5):644-646. https://doi.org/10.1007/s10517-012-1787-4 - DOI - PubMed
    1. Mab’kovksaya IN, Gonchar OA, Nosar’ VI, Rozova EV, Bratus’ LV, Kolesnikova EE, Putii YuV, Karaban IN. Mitochondrial dysfunction and oxidative disturbances in the brain of rats with simulated Parkinsonian syndrome: the corrective effect of capicor. Fiziol. Zh. 2018;64(4):82-90.
    1. Frelikh GA, Polomeeva NU, Vasil’ev AS, Udut VV. State-ofthe art methods of evaluation of mitochondrial function. Sib. Med. Zh. 2013;28(3):7-13. Russian.
    1. Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease. Science. 2017;357:1255-1261. https://doi.org/10.1126/science.aam9080
    1. Campello S, Scorrano L. Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep. 2010;11(9):678-684. https://doi.org/10.1038/embor.2010.115

LinkOut - more resources