DNA-based screening and population health: a points to consider statement for programs and sponsoring organizations from the American College of Medical Genetics and Genomics (ACMG)

Affiliations

¹ Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
² Genomics Consultant, Brookline, MA, USA.
³ Washington State Department of Health (Ret.), Kent, WA, USA.
⁴ The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁵ HudsonAlpha, Huntsville, AL, USA.
⁶ Clinical Pediatric, Nationwide Children's Hospital, Columbus, OH, USA.
⁷ GeneDx, Gaithersburg, MD, USA.
⁸ Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
⁹ Department of Epidemiology, University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, FL, USA.
¹⁰ Division of Medical Genetics, Department of Pediatrics and Division of Hematology-Oncology, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, USA.
¹¹ Clinical Genetics Program, San Francisco VA Health Care System, San Francisco, CA, USA.
¹² Department of Pathology and Laboratory Medicine, Alpert Medical School, Brown University, Providence, RI, USA.
¹³ Women and Infants Hospital, Providence, RI, USA.
¹⁴ Self-employed, Washington, DC, USA.

Free article

Michael F Murray et al. Genet Med. 2021 Jun.

Free article

. 2021 Jun;23(6):989-995.

doi: 10.1038/s41436-020-01082-w. Epub 2021 Mar 16.

¹ Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
² Genomics Consultant, Brookline, MA, USA.
³ Washington State Department of Health (Ret.), Kent, WA, USA.
⁴ The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁵ HudsonAlpha, Huntsville, AL, USA.
⁶ Clinical Pediatric, Nationwide Children's Hospital, Columbus, OH, USA.
⁷ GeneDx, Gaithersburg, MD, USA.
⁸ Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
⁹ Department of Epidemiology, University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, FL, USA.
¹⁰ Division of Medical Genetics, Department of Pediatrics and Division of Hematology-Oncology, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, USA.
¹¹ Clinical Genetics Program, San Francisco VA Health Care System, San Francisco, CA, USA.
¹² Department of Pathology and Laboratory Medicine, Alpert Medical School, Brown University, Providence, RI, USA.
¹³ Women and Infants Hospital, Providence, RI, USA.
¹⁴ Self-employed, Washington, DC, USA.

No abstract available

Comment in

From genes to public health: are we ready for DNA-based population screening?
Khoury MJ, Dotson WD. Khoury MJ, et al. Genet Med. 2021 Jun;23(6):996-998. doi: 10.1038/s41436-021-01141-w. Epub 2021 Mar 31. Genet Med. 2021. PMID: 33790422 Free PMC article. No abstract available.

1. Wald, N. J. The definition of screening. J. Med. Screen. 8, 1 (2001). - DOI
1. Gilbert, W. DNA sequencing, today and tomorrow. Hosp. Pract. (Off. Ed.) 26, 165–169, 172, 174 (1991). - DOI
1. Wilson, J. M. & Jungner, Y. G. Principles and practice of mass screening for disease. Bol. Oficina Sanit. Panam. 65, 281–393 (1968). - PubMed
1. Bean, L. et al. DNA-based screening and personal health: a points to consider statement for individuals and healthcare providers from the American College of Medical Genetics and Genomics (ACMG). Genet. Med. (in press).
1. Green, R. C. et al. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet. Med. 15, 565–574 (2013). - DOI