Isoform-dependent APOE secretion modulates neuroinflammation
- PMID: 33727705
- DOI: 10.1038/s41582-021-00483-y
Isoform-dependent APOE secretion modulates neuroinflammation
Comment on
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Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation.Glia. 2021 Jun;69(6):1478-1493. doi: 10.1002/glia.23974. Epub 2021 Feb 8. Glia. 2021. PMID: 33556209 Free PMC article.
References
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- Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C. C. & Bu, G. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. Nat. Rev. Neurol. 15, 501–518 (2019). - DOI
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- Kloske, C. M. & Wilcock, D. M. The important interface between apolipoprotein E and neuroinflammation in Alzheimer’s disease. Front. Immunol. 11, 754 (2020). - DOI
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- Lanfranco, M. F., Sepulveda, J., Kopetsky, G. & Rebeck, G. W. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia https://doi.org/10.1002/glia.23974 (2021). - DOI - PubMed
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- Zhang, Y. et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34, 11929–11947 (2014). - DOI
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- Lynch, J. R. et al. APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. J. Biol. Chem. 278, 48529–48533 (2003). - DOI
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