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. 2021 Jun;36(6):1464-1466.
doi: 10.1002/mds.28570. Epub 2021 Mar 17.

Application of the Updated Movement Disorder Society Criteria for Prodromal Parkinson's Disease to a Population-Based 10-Year Study

Kathrin Marini  1 , Klaus Seppi  1 , Lena Tschiderer  1 , Stefan Kiechl  1   2 , Heike Stockner  1 , Peter Willeit  1   3 , Johann Willeit  1 , Atbin Djamshidian  1 , Gregorio Rungger  4 , Werner Poewe  1 , Philipp Mahlknecht  1
Affiliations

Application of the Updated Movement Disorder Society Criteria for Prodromal Parkinson's Disease to a Population-Based 10-Year Study

Kathrin Marini et al. Mov Disord. 2021 Jun.
No abstract available

Keywords: epidemiology; preclinical/prediagnostic Parkinson's disease; prodromal Parkinson's disease (PD); risk factors.

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Figures

FIG. 1.
FIG. 1.
Upper row: scatterplot and Spearman rank correlation analyses with original probabilities (2015 criteria) plotted on the x‐axis and updated probabilities (2019 criteria) on the y‐axis. Numbers in parentheses indicate 95% confidence intervals. The upper dashed lines represent the 80% probability cutoff for probable prodromal Parkinson's disease (PD) as defined per Movement Disorder Society (MDS) research criteria, the middle dash‐dotted and the lower dotted lines represent 50% and 30% probability cutoffs, also mentioned by the MDS Task Force.1, 7 Middle row: scatterplots of the absolute baseline posttest probability for prodromal PD, illustrated for cumulative cases with incident PD at 5‐year and 10‐year follow‐ups. Incident cases at respective follow‐ups are shown in black and incident cases from previous follow‐ups in are shown in lighter gray. The resulting predictive accuracy measures are given in Table S2. Lower row: scatterplots of the relative change in posttest probabilities with the two criteria versions (probability according to updated criteria minus probability according to original criteria) in the various groups. In the middle and lower rows, single values are given with the respective group median (25th to 75th percentiles) and p‐values were calculated with the paired Wilcoxon signed‐rank test (middle row) or Mann‐Whitney U test (lower row). [Color figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

References

    1. Berg D, Postuma RB, Adler CH, et al. MDS research criteria for prodromal Parkinson's disease. Mov Disord 2015;30:1600–1611. - PubMed
    1. Pilotto A, Heinzel S, Suenkel U, et al. Application of the Movement Disorder Society prodromal Parkinson's disease research criteria in 2 independent prospective cohorts. Mov Disord 2017;32:1025–1034. - PubMed
    1. Mahlknecht P, Gasperi A, Djamshidian A, et al. Performance of the Movement Disorders Society criteria for prodromal Parkinson's disease: a population‐based 10‐year study. Mov Disord 2018;33:405–413. - PubMed
    1. Giagkou N, Maraki MI, Yannakoulia M, et al. A prospective validation of the updated Movement Disorders Society research criteria for prodromal Parkinson's disease. Mov Disord 2020;35:1802–1809. - PubMed
    1. Heinzel S, Berg D, Gasser T, et al. Update of the MDS research criteria for prodromal Parkinson's disease. Mov Disord 2019;34:1464–1470. - PubMed

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