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. 2021 Feb;28(1):27-39.
doi: 10.11005/jbm.2021.28.1.27. Epub 2021 Feb 28.

Physical Activity and Bone Health in Men: A Systematic Review and Meta-Analysis

Maureen C Ashe  1   2 , Isis Kelly Dos Santos  3 , Nicola Y Edward  1 , Laura A Burnett  1 , Rosanne Barnes  1 , Lena Fleig  4 , Joseph H Puyat  5 , Joanna E M Sale  6 , Heather A McKay  1   2 , Lora M Giangregorio  7   8
Affiliations

Physical Activity and Bone Health in Men: A Systematic Review and Meta-Analysis

Maureen C Ashe et al. J Bone Metab. 2021 Feb.

Abstract

Background: Research on osteoporosis and physical activity often focuses on women. We aimed to conduct a systematic review to assess the benefits and harms of physical activity interventions for men's bone health.

Methods: We used standard methods and searched for randomized controlled trials (RCTs) (duration, ≥6 months) published in all languages across multiple databases and trial registries. The last search was conducted on July 22, 2020.

Results: We included 11 studies (14 publications), resulting in a sample of N=723 men (range, 17-132 participants). We found low-certainty evidence that physical activity has little influence on the areal bone mineral density (aBMD) at the total hip (5 RCTs, N=324; mean difference [MD], 0.03 [95 confidence interval (CI), 0.01 to 0.05]) and little or no influence on the aBMD at the femoral neck (3 RCTs, N=186; MD, 0.00 [95% CI, -0.04 to 0.04]), lumbar spine (3 RCTs; N=213; MD, 0.05 [95% CI, -0.01 to 0.11]), and whole body (4 RCTs, N=203; MD, -0.00 [95% CI, -0.03 to 0.02]).

Conclusions: We found low-certainty evidence that physical activity (≥6 months) has some effect on the total hip in men, but new evidence may change this finding. This review highlights the gap in the evidence on specific intervention prescriptions that can benefit the bone geometry, structure, microarchitecture, and, ultimately, bone strength in men. Future research should engage in comprehensive reporting of harms, quality of life outcomes, advanced imaging findings, and long-term interventions.

Keywords: Bone and bones.

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Conflict of interest statement

Conflict of interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram.
Fig. 2
Fig. 2
Risk of bias ratings for individual studies (A) and overall summary of risk of bias for the collective evidence (B).
Fig. 3
Fig. 3
Forest plots for areal bone mineral density (aBMD) evidence for femoral neck (A), total hip (B), lumbar spine (C), and whole body (D). SD, standard deviation; MD, mean difference; CI, confidence interval.
See this image and copyright information in PMC

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