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Observational Study
. 2021 May 5;41(5):1801-1809.
doi: 10.1161/ATVBAHA.121.316083. Epub 2021 Mar 18.

Impaired Peripheral Microvascular Function and Risk of Major Adverse Cardiovascular Events in Patients With Coronary Artery Disease

An Young  1   2 , Mariana Garcia  1   2 , Samaah M Sullivan  1 , Chang Liu  1 , Kasra Moazzami  1   2 , Yi-An Ko  3 , Amit J Shah  1   2   4 , Jeong Hwan Kim  2 , Brad Pearce  1 , Irina Uphoff  1 , J Douglas Bremner  5   4 , Paolo Raggi  6 , Arshed Quyyumi  2 , Viola Vaccarino  1   2
Affiliations
Observational Study

Impaired Peripheral Microvascular Function and Risk of Major Adverse Cardiovascular Events in Patients With Coronary Artery Disease

An Young et al. Arterioscler Thromb Vasc Biol. .

Abstract

[Figure: see text].

Keywords: coronary artery disease; hyperemia index; interleukin; myocardial infarction; risk factors.

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Figures

Figure 1.
Figure 1.. Kaplan Meier Analysis of Major Adverse Cardiovascular Outcomes and Reactive Hyperemia Index by Tertiles (Unadjusted)
Panel A. Cumulative Incidence of Cardiovascular Death and Myocardial Infarction Panel B. Cumulative Incidence of Cardiovascular Death, Myocardial Infarction, and Heart Failure Hospitalization
Figure 1.
Figure 1.. Kaplan Meier Analysis of Major Adverse Cardiovascular Outcomes and Reactive Hyperemia Index by Tertiles (Unadjusted)
Panel A. Cumulative Incidence of Cardiovascular Death and Myocardial Infarction Panel B. Cumulative Incidence of Cardiovascular Death, Myocardial Infarction, and Heart Failure Hospitalization
Figure 2.
Figure 2.. Forest Plot for the Adjusted Association of Reactive Hyperemia Index with Individual Components of the Composite Cardiac Endpoints. Values Shown are Subdistribution Hazard Ratios and 95% Confidence Intervals per Standard Deviation Decrease in Reactive Hyperemia Index.
Estimates are adjusted for age, sex, race, income, hypertension, diabetes, dyslipidemia, smoking status, BMI, history of MI, heart failure, Gensini score, and medication use (beta blockers, angiotensin converting enzyme inhibitors/angiotensin receptor blockers or statins)
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