Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 17;25(1):108.
doi: 10.1186/s13054-021-03535-3.

Long-term outcomes after critical illness: recent insights

Affiliations

Long-term outcomes after critical illness: recent insights

Anne-Françoise Rousseau et al. Crit Care. .

Abstract

Intensive care survivors often experience post-intensive care sequelae, which are frequently gathered together under the term "post-intensive care syndrome" (PICS). The consequences of PICS on quality of life, health-related costs and hospital readmissions are real public health problems. In the present Viewpoint, we summarize current knowledge and gaps in our understanding of PICS and approaches to management.

Keywords: Core set; Critically ill; Follow-up; ICU-acquired weakness; Intensive care unit; Muscle weakness; Post-intensive care syndrome; Post-traumatic stress disorder; Quality of care.

PubMed Disclaimer

Conflict of interest statement

AFR has no conflicts of interests to declare. HCP is an Associate Editor of Critical Care and a panel member of the Surviving Sepsis Campaign guidelines. She has no other conflicts of interests to declare. SJB is an Associate Editor of Critical Care. He has no other conflicts of interests to declare. BW has no conflicts of interests to declare. EA is an Associate Editor of Critical Care. He has no other conflicts of interests to declare. JC has no conflicts of interests to declare. NL has no conflicts of interests to declare. CLH has no conflicts of interests to declare. SWC has no conflicts of interests to declare. JLV is Editor-in-Chief of Critical Care. He has no other conflicts of interests to declare. JCP is an Associate Editor of Critical Care. He has no other conflicts of interests to declare.

Figures

Fig. 1
Fig. 1
A proposed expanded definition of the post-intensive care syndrome (PICS), including contributing factors (on the left side of the figure) and consequences (on the right side of the figure), current (gray circles) and potential new (white circles) components. ICU-AW; intensive care unit acquired weakness

References

    1. Krumholz HM. Post-hospital syndrome—an acquired, transient condition of generalized risk. N Engl J Med. 2013;368:100–102. doi: 10.1056/NEJMp1212324. - DOI - PMC - PubMed
    1. Needham DM, Davidson J, Cohen H, Hopkins RO, Weinert C, Wunsch H, et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med. 2012;40:502–509. doi: 10.1097/CCM.0b013e318232da75. - DOI - PubMed
    1. Cuthbertson BH, Roughton S, Jenkinson D, Maclennan G, Vale L. Quality of life in the five years after intensive care: a cohort study. Crit Care. 2010;14:R6. doi: 10.1186/cc8848. - DOI - PMC - PubMed
    1. Hirshberg EL, Wilson EL, Stanfield V, Kuttler KG, Majercik S, Beesley SJ, et al. Impact of critical illness on resource utilization: A comparison of use in the year before and after ICU admission. Crit Care Med. 2019;47:1497–1504. doi: 10.1097/CCM.0000000000003970. - DOI - PMC - PubMed
    1. Langhans C, Weber-Carstens S, Schmidt F, Hamati J, Kny M, Zhu X, et al. Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy. PLoS ONE. 2014;9:e92048. doi: 10.1371/journal.pone.0092048. - DOI - PMC - PubMed

MeSH terms

Supplementary concepts