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Case Reports
. 2021 Mar 17;14(3):e236296.
doi: 10.1136/bcr-2020-236296.

Disulfiram-induced epileptic seizures

Violeta Nogueira  1 , Mafalda Azevedo Mendes  2 , Inês Pereira  2 , Joana Teixeira  3
Affiliations
Case Reports

Disulfiram-induced epileptic seizures

Violeta Nogueira et al. BMJ Case Rep. .

Abstract

Disulfiram has been widely used for over six decades in the treatment of alcohol dependence, as an aversive therapeutic agent. Despite having very few side effects when taken without concurrent alcohol consumption, some of these may underlie serious clinical complications. Epileptic seizure induction is a rare adverse effect of disulfiram and its aetiological mechanism is unknown. We present a hospitalised 47-year-old male patient with two episodes of generalised tonic-clonic seizures during treatment with disulfiram while abstinent from alcohol.

Keywords: drugs: psychiatry; epilepsy and seizures; safety.

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Conflict of interest statement

Competing interests: None declared.

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