The authors reply

Youssef Bennis^{1

2}, Marc E De Broe³, Jean-Daniel Lalau^{4

5}

Affiliations

¹ Department of Clinical Pharmacology, Amiens University Hospital, Amiens, France.
² MP3CV Laboratory, EA7517, University of Picardie Jules Verne, Amiens, France.
³ Laboratory of Pathophysiology, University of Antwerp, Wilrijk, Belgium.
⁴ Department of Endocrinology-Diabetology-Nutrition, Amiens University Hospital, Amiens, France.
⁵ PériTox UMR_I 01, University of Picardie Jules Verne, Amiens, France.

Comment

Youssef Bennis et al. Crit Care Med. 2021.

. 2021 Apr 1;49(4):e464-e465.

doi: 10.1097/CCM.0000000000004902.

Youssef Bennis^{1

2}, Marc E De Broe³, Jean-Daniel Lalau^{4

5}

¹ Department of Clinical Pharmacology, Amiens University Hospital, Amiens, France.
² MP3CV Laboratory, EA7517, University of Picardie Jules Verne, Amiens, France.
³ Laboratory of Pathophysiology, University of Antwerp, Wilrijk, Belgium.
⁴ Department of Endocrinology-Diabetology-Nutrition, Amiens University Hospital, Amiens, France.
⁵ PériTox UMR_I 01, University of Picardie Jules Verne, Amiens, France.

No abstract available

Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

A Study of Associations Between Plasma Metformin Concentration, Lactic Acidosis, and Mortality in an Emergency Hospitalization Context.
Bennis Y, Bodeau S, Batteux B, Gras-Champel V, Masmoudi K, Maizel J, De Broe ME, Lalau JD, Lemaire-Hurtel AS. Bennis Y, et al. Crit Care Med. 2020 Dec;48(12):e1194-e1202. doi: 10.1097/CCM.0000000000004589. Crit Care Med. 2020. PMID: 33003077
Plasma Metformin Levels at Almost 24 Hours Would Help With the Delicate Decision to Start Renal Replacement Therapy: We Disagree as Lactate That Is More Widely and Early Available Should Be a Much Better Trigger to Start Renal Replacement Therapy!
Honore PM, Redant S, Kaefer K, Kugener L, Barreto Gutierrez L, Attou R, Gallerani A, De Bels D. Honore PM, et al. Crit Care Med. 2021 Apr 1;49(4):e463-e464. doi: 10.1097/CCM.0000000000004860. Crit Care Med. 2021. PMID: 33731623 No abstract available.

1. Honore PM, Redant S, Kaefer K. et al: Plasma Metformin Levels at Almost 24 Hours Would Help With the Delicate Decision to Start Renal Replacement Therapy: We Disagree as Lactate That Is More Widely and Early Available Should Be a Much Better Trigger to Start Renal Replacement Therapy! Crit Care Med. 2020; 49:e464–e465
1. Bennis Y, Bodeau S, Batteux B, et al. A Study of Associations Between Plasma Metformin Concentration, Lactic Acidosis, and Mortality in an Emergency Hospitalization Context. Crit Care Med. 2020; 48:e1194–e1202
1. Lalau JD, Kajbaf F, Protti A, et al. Metformin-associated lactic acidosis (MALA): Moving towards a new paradigm. Diabetes Obes Metab. 2017; 19:1502–1512
1. Kajbaf F, Bennis Y, Hurtel-Lemaire AS, et al. Unexpectedly long half-life of metformin elimination in cases of metformin accumulation. Diabet Med. 2016; 33:105–110
1. Nguyen HB, Rivers EP, Knoblich BP, et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med. 2004; 32:1637–1642