Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?
- PMID: 33731635
- DOI: 10.1097/CCM.0000000000004873
Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?
Conflict of interest statement
The author has disclosed that she does not have any potential conflicts of interest.
Comment in
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The authors reply.Crit Care Med. 2021 Apr 1;49(4):e479-e480. doi: 10.1097/CCM.0000000000004909. Crit Care Med. 2021. PMID: 33731636 No abstract available.
Comment on
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Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C.Crit Care Med. 2021 Feb 1;49(2):e179-e190. doi: 10.1097/CCM.0000000000004770. Crit Care Med. 2021. PMID: 33239507 Free PMC article.
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References
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- Lankadeva YR, Peiris RM, Okazaki N, et al. Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C. Crit Care Med. 2021; 49:e179–e190
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- Carr AC, Cook J. Intravenous vitamin c for cancer therapy - identifying the current gaps in our knowledge. Front Physiol. 2018; 9:1182
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- Carr AC. Chen Q, Vissers M. Vitamin C in pneumonia and sepsis. Vitamin C: New Biochemical and Functional Insights. Oxidative Stress and Disease. 2020, Boca Raton, FL: CRC Press/Taylor & Francis115–135 In
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- Fowler AA III, Truwit JD, Hite RD, et al. Effect of vitamin c infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI randomized clinical trial. JAMA. 2019; 322:1261–1270
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- Zhang J, Rao X, Li Y, et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care. 2021; 11:5
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