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Comment
. 2021 Apr 1;49(4):e477-e478.
doi: 10.1097/CCM.0000000000004873.

Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?

Anitra C Carr  1
Affiliations
Comment

Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?

Anitra C Carr. Crit Care Med. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author has disclosed that she does not have any potential conflicts of interest.

Comment in

  • The authors reply.
    May CN, Lankadeva YR, Bellomo R. May CN, et al. Crit Care Med. 2021 Apr 1;49(4):e479-e480. doi: 10.1097/CCM.0000000000004909. Crit Care Med. 2021. PMID: 33731636 No abstract available.

Comment on

References

    1. Lankadeva YR, Peiris RM, Okazaki N, et al. Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C. Crit Care Med. 2021; 49:e179–e190
    1. Carr AC, Cook J. Intravenous vitamin c for cancer therapy - identifying the current gaps in our knowledge. Front Physiol. 2018; 9:1182
    1. Carr AC. Chen Q, Vissers M. Vitamin C in pneumonia and sepsis. Vitamin C: New Biochemical and Functional Insights. Oxidative Stress and Disease. 2020, Boca Raton, FL: CRC Press/Taylor & Francis115–135 In
    1. Fowler AA III, Truwit JD, Hite RD, et al. Effect of vitamin c infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI randomized clinical trial. JAMA. 2019; 322:1261–1270
    1. Zhang J, Rao X, Li Y, et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care. 2021; 11:5

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