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Comment
. 2021 Apr 1;49(4):e479-e480.
doi: 10.1097/CCM.0000000000004909.

The authors reply

Clive N May  1 , Yugeesh R Lankadeva  1 , Rinaldo Bellomo  2
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Comment

The authors reply

Clive N May et al. Crit Care Med. .
No abstract available

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References

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    1. Lankadeva YR, Peiris RM, Okazaki N, et al.: Reversal of the pathophysiological responses to gram-negative sepsis by megadose vitamin C. Crit Care Med 2021; 49:e179–e190
    1. Fowler AA 3rd, Truwit JD, Hite RD, et al.: Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI randomized clinical trial. JAMA 2019; 322:1261–1270
    1. Fujii T, Luethi N, Young PJ, et al.; VITAMINS Trial Investigators: Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: The VITAMINS randomized clinical trial. JAMA 2020; 323:423–431
    1. Marik PE, Khangoora V, Rivera R, et al.: Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: A retrospective before-after study. Chest 2017; 151:1229–1238

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