The authors reply
- PMID: 33731636
- DOI: 10.1097/CCM.0000000000004909
The authors reply
Comment on
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Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C.Crit Care Med. 2021 Feb 1;49(2):e179-e190. doi: 10.1097/CCM.0000000000004770. Crit Care Med. 2021. PMID: 33239507 Free PMC article.
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Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?Crit Care Med. 2021 Apr 1;49(4):e477-e478. doi: 10.1097/CCM.0000000000004873. Crit Care Med. 2021. PMID: 33731635 No abstract available.
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References
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- Carr AC: Is “Mega-Dose” IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?: Crit Care Med 2021; 49:e477–e478
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- Lankadeva YR, Peiris RM, Okazaki N, et al.: Reversal of the pathophysiological responses to gram-negative sepsis by megadose vitamin C. Crit Care Med 2021; 49:e179–e190
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- Fowler AA 3rd, Truwit JD, Hite RD, et al.: Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI randomized clinical trial. JAMA 2019; 322:1261–1270
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- Fujii T, Luethi N, Young PJ, et al.; VITAMINS Trial Investigators: Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: The VITAMINS randomized clinical trial. JAMA 2020; 323:423–431
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- Marik PE, Khangoora V, Rivera R, et al.: Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: A retrospective before-after study. Chest 2017; 151:1229–1238
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