Translational research on Myology and Mobility Medicine: 2021 semi-virtual PDM3 from Thermae of Euganean Hills, May 26 - 29, 2021

Abstract

On 19-21 November 2020, the meeting of the 30 years of the Padova Muscle Days was virtually held while the SARS-CoV-2 epidemic was hitting the world after a seemingly quiet summer. During the 2020-2021 winter, the epidemic is still active, despite the start of vaccinations. The organizers hope to hold the 2021 Padua Days on Myology and Mobility Medicine in a semi-virtual form (2021 S-V PDM3) from May 26 to May 29 at the Thermae of Euganean Hills, Padova, Italy. Here the program and the Collection of Abstracts are presented. Despite numerous world problems, the number of submitted/selected presentations (lectures and oral presentations) has increased, prompting the organizers to extend the program to four dense days.

Fig 1.

SL in the 4 different DJ phases (JO, GC, MAJ, PO) in 1g (red dots), hypo-gravity (blue dots) and hyper-gravity (green dots). The L-T relationship of hypo- and hyper-gravity has been shifted on the x axis to the left and right, respectively, to allow for dots visualisation.

Fig 1.

Left Panel: Nuclear clumps are predominant after many years of denervation in human muscle fibers.¹ A, Normal muscle; B, 0.8- year denervated muscle characterized by atrophy of myofibers and seldom central nuclei; C, 4.1-year denervated muscle showing severely atrophic myofibers in which contractile apparatus is almost absent and three or more clumped nuclei can be identified in oblique muscle sections. Scale bars: A, B, C = 20 μm.

Fig 1.

Identification of distinctively expressed molecular markers, in particular Pax7, has facilitated detection of satellite cells and their proliferating and differentiating progeny in the muscle tissue, in isolated myofibers, and in cultures derived from satellite cells. The satellite cells have also gained the status of “myogenic stem cells,” being capable of self-renewal in addition to producing differentiated progeny.