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. 2021 Jul 1;116(7):1533-1536.
doi: 10.14309/ajg.0000000000001225.

Esophageal Epidermoid Metaplasia: Clinical Characteristics and Risk of Esophageal Squamous Neoplasia

Amrit K Kamboj  1 , Ying Y Gibbens  2 , Catherine E Hagen  3 , Kenneth K Wang  1 , Prasad G Iyer  1 , David A Katzka  1
Affiliations

Esophageal Epidermoid Metaplasia: Clinical Characteristics and Risk of Esophageal Squamous Neoplasia

Amrit K Kamboj et al. Am J Gastroenterol. .

Abstract

Introduction: Esophageal epidermoid metaplasia (EEM) is a rare disease.

Methods: Patients with EEM diagnosed between 2014 and 2020 were reviewed.

Results: Forty EEM cases were identified. EEM occurred in 9 (23%) patients before, concordant, or after esophageal squamous cell carcinoma (ESCC). EEM was associated with previous esophageal lichen planus in 5 patients, Barrett's esophagus 7, and esophageal adenocarcinoma 1. EEM was focal in 28 (70%) or diffuse in 12 (30%) and not detected in 45% on recent previous endoscopy.

Discussion: EEM is a premalignant underrecognized condition associated with multiple conditions. Close follow-up or endoscopic treatment may be warranted because of its ESCC association.

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