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Comment
. 2021 Mar 18;137(11):1436-1437.
doi: 10.1182/blood.2020009968.

Sorting biologic subtypes of primary CNS lymphoma

Mark Roschewski  1 , James D Phelan  1
Affiliations
Comment

Sorting biologic subtypes of primary CNS lymphoma

Mark Roschewski et al. Blood. .

Abstract

In this issue of Blood, Gandhi et al studied 91 cases of primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system (CNS) (PCNSL) and compared the biologic features of tumors associated with Epstein-Barr virus (EBV) to tumors that are EBV− using digital gene expression signatures and customized hybrid-capture targeted sequencing panels.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
Primary CNS lymphoma can be subdivided into EBV− and EBV-associated subtypes based on unique genetic alterations, gene expression signatures, and functional and microenvironmental differences. These biologic differences suggest that potential therapeutic strategies should be tailored within subtypes. ABC, activated B cell; amp, amplifications; BCR, B-cell receptor; BTK, Bruton tyrosine kinase; CAR T, chimeric antigen receptor T cell; del, deletions; IMiD, immunomodulatory imide drug; My-T-BCR, MYD88-TLR9-BCR supercomplex; mut, mutation; PI3K, phosphoinositide 3-kinase.
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Comment on

References

    1. Gandhi MK, Hoang T, Law SC, et al. . EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity. Blood. 2021;137(11):1468-1477. - PMC - PubMed
    1. Young RM, Phelan JD, Shaffer AL, et al. . Taming the heterogeneity of aggressive lymphomas for precision therapy. Ann Rev Cancer Biol. 2019;3:429-455.
    1. Alizadeh AA, Eisen MB, Davis RE, et al. . Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403(6769):503-511. - PubMed
    1. Schmitz R, Wright GW, Huang DW, et al. . Genetics and pathogenesis of diffuse large B-cell lymphoma. N Engl J Med. 2018;378(15):1396-1407. - PMC - PubMed
    1. Chapuy B, Stewart C, Dunford AJ, et al. . Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes [published correction appears in Nat Med. 2018;24(8):1292]. Nat Med. 2018;24(5):679-690. - PMC - PubMed

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