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. 2021 Apr 26;101(4):adv00435.
doi: 10.2340/00015555-3790.

Epidemiology of Hyperhidrosis in Danish Blood Donors

Mattias A S Henning  1 , Kristina S Ibler, Isabella Loft, Henrik Ullum, Christian Erikstrup, Kaspar R Nielsen, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sørensen, Kristoffer S Burgdorf, Susan Mikkelsen, Thomas F Hansen, Ole B Pedersen, Gregor B E Jemec
Affiliations

Epidemiology of Hyperhidrosis in Danish Blood Donors

Mattias A S Henning et al. Acta Derm Venereol. .

Abstract

The risk factors and disease implications of hyper-hidrosis are unknown. The objectives of this retrospective cohort study were to estimate the prevalence of hyperhidrosis and to compare demographic, life-style, and socioeconomic parameters in blood donors with and without self-reported or hospital-diagnosed hyperhidrosis. The study included blood donors from the Danish Blood Donor Study for the period 2010-2019. Registry data were collected from Statistics Denmark. Overall, 2,794 of 30,808 blood donors (9.07%; 95% confidence interval (95% CI) 8.75-9.40) had self- reported hyperhidrosis and 284 of 122,225 (0.23%; 95% CI 0.21-0.26) had hospital-diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with smoking (odds ratio (OR) 1.17; 95% CI 1.05-1.31), overweight (OR 1.72; 95% CI 1.58-1.87), "unemployed" (OR 1.60; 95% CI 1.24-2.08), "short education" (OR 0.76; 95% CI 0.64-0.90), and lower income (beta-coefficient -26,121; 95% CI -37,931, -14,311). Hospital-diagnosed hyperhidrosis did not differ from controls. Thus, self-reported hyperhidrosis was associated with potential hyperhidrosis risk factors (smoking, overweight) and disease implications (unemployment, low education level and income).

Keywords: hyperhidrosis; overweight; smoking; socioeconomic factors; cohort studies.

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Conflict of interest statement

Conflicts of interest: MASH reports grants from Leo Foundation, Denmark (number LF 18002), during the conduct of the study. GBJ reports grants and personal fees from Abbvie, personal fees from Coloplast, personal fees from Chemocentryx, personal fees from LEO pharma, grants from LEO Foundation, grants from Afyx, personal fees from Incyte, grants and personal fees from InflaRx, grants from Janssen-Cilag, grants and personal fees from Novartis, grants and personal fees from UCB, grants from CSL Behring, grants from Regeneron, grants from Sanofi, personal fees from Kymera, and personal fees from VielaBio, outside the submitted work. The other authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Study flow diagram of inclusion and exclusion of blood donors. DBDS: Danish Blood Donor Study; HH: hyperhidrosis; ICD-10: International Classification of Disease-10.
See this image and copyright information in PMC

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