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. 2021 Jul;98(1):37-42.
doi: 10.1111/tan.14256. Epub 2021 Apr 13.

Association of HLA-DRB1*09:01 with severe COVID-19

Alitzel Anzurez  1   2 , Izumi Naka  3 , Shoji Miki  1 , Kaori Nakayama-Hosoya  1 , Mariko Isshiki  3 , Yusuke Watanabe  3 , Midori Nakamura-Hoshi  1 , Sayuri Seki  1 , Takayuki Matsumura  4 , Tomohiro Takano  4 , Taishi Onodera  4 , Yu Adachi  4 , Saya Moriyama  4 , Kazutaka Terahara  4 , Natsuo Tachikawa  5 , Yoshihiro Yoshimura  5 , Hiroaki Sasaki  5 , Hiroshi Horiuchi  5 , Nobuyuki Miyata  5 , Kazuhito Miyazaki  5 , Michiko Koga  6 , Kazuhiko Ikeuchi  6 , Hiroyuki Nagai  6 , Makoto Saito  6 , Eisuke Adachi  6 , Hiroshi Yotsuyanagi  6 , Satoshi Kutsuna  7 , Akira Kawashima  7 , Yusuke Miyazato  7 , Noriko Kinoshita  7 , Chiyoko Kouno  8 , Kensuke Tanaka  8 , Yoshimasa Takahashi  4 , Tadaki Suzuki  9 , Tetsuro Matano  1   2   10 , Jun Ohashi  3 , Ai Kawana-Tachikawa  1   2   10
Affiliations

Association of HLA-DRB1*09:01 with severe COVID-19

Alitzel Anzurez et al. HLA. 2021 Jul.

Abstract

HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB1*09:01 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID-19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID-19.

Keywords: Japan; association; coronavirus disease 2019; human leukocyte antigen; risk factor; severe acute respiratory syndrome coronavirus 2.

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Conflict of interest statement

The authors declare no conflicts of interest associated with this manuscript.

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