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Review
. 2021 Mar 18;17(3):e1009341.
doi: 10.1371/journal.ppat.1009341. eCollection 2021 Mar.

Bacteria make surgical strikes on host ubiquitin signaling

Tyler G Franklin  1 , Jonathan N Pruneda  1
Affiliations
Review

Bacteria make surgical strikes on host ubiquitin signaling

Tyler G Franklin et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Bacteria manipulate specific poly-ubiquitin signals.
Secreted bacterial effectors are shown positively or negatively regulating specific poly-ubiquitin signal types. Individual poly-ubiquitin chains are represented by their di-ubiquitin crystal structures (PDB codes 2W9N, 2XK5, 2XEW, 6QML, 4S22, 4XYZ, 5GOI, and 2JF5). Current models for the signaling roles of each poly-ubiquitin chain type are shown below. DDR, DNA damage response; UPS, ubiquitin–proteasome system.
See this image and copyright information in PMC

References

    1. Swatek KN, Komander D. Ubiquitin modifications. Cell Res. 2016;26:399–422. 10.1038/cr.2016.39 - DOI - PMC - PubMed
    1. Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, et al.. Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses. Biochem Biophys Res Commun. 2005;333:531–9. 10.1016/j.bbrc.2005.05.145 - DOI - PubMed
    1. Wandel MP, Pathe C, Werner EI, Ellison CJ, Boyle KB, Malsburg v d A, et al.. GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8. Cell Host Microbe. 2017;22:507–18. 10.1016/j.chom.2017.09.007 - DOI - PMC - PubMed
    1. Li P, Jiang W, Yu Q, Liu W, Zhou P, Li J, et al.. Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence. Nature. 2017;551:378–83. 10.1038/nature24467 - DOI - PubMed
    1. Rytkönen A, Poh J, Garmendia J, Boyle C, Thompson A, Liu M, et al.. SseL, a Salmonella deubiquitinase required for macrophage killing and virulence. Proc Natl Acad Sci U S A. 2007;104:3502–7. 10.1073/pnas.0610095104 - DOI - PMC - PubMed

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