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Editorial
. 2021 Aug 2;15(8):1247-1249.
doi: 10.1093/ecco-jcc/jjab027.

Mycobacterium Avium Subspecies Paratuberculosis Infection and Biological Treatment of IBD: Cause or Consequence?

E Proietti  1 , G M Fuhler  1 , M P Peppelenbosch  1
Affiliations
Editorial

Mycobacterium Avium Subspecies Paratuberculosis Infection and Biological Treatment of IBD: Cause or Consequence?

E Proietti et al. J Crohns Colitis. .
No abstract available

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Figures

Figure 1.
Figure 1.
[A] Mycobacterium-associated granuloma. [B] Ziehl–Neelsen staining for mycobacterium detection in another sample from the same patient as in A [different location].
Figure 2.
Figure 2.
The detected anti-MAP antibody levels can be explained by three possible scenarios. First scenario: MAP infection occurs prior to the development of IBD and can therefore be seen as a possible aetiological cause of CD and UC. Second scenario: higher levels of anti-MAP antibodies in IBD patients compared to healthy individuals may also be explained by a greater risk for IBD patients to contract MAP infection. In both cases the need for surgery does not correlate with antibodies levels. Third scenario: patients undergoing biological therapies may be at increased risk of developing MAP infection, resulting in higher anti-MAP antibodies. IBD: inflammatory bowel disease, MAP: Mycobacterium avium subsp. paratuberculosis, Ab: antibody
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References

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