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Comment
. 2021 Mar 17;109(6):911-913.
doi: 10.1016/j.neuron.2021.02.022.

Timing isn't everything: opposing roles for perisomatic inhibition

Adam P Caccavano  1 , Chris J McBain  2
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Free article
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Timing isn't everything: opposing roles for perisomatic inhibition

Adam P Caccavano et al. Neuron. .
Free article

Abstract

Perisomatic inhibition from parvalbumin-containing (PV) interneurons is critical for timing, but the role of cholecystokinin-containing (CCK) interneurons remains obscure. Utilizing a novel mouse model, Dudok et al. demonstrate fundamentally distinct behavioral roles for these neuronal subpopulations during behavior.

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  • Alternating sources of perisomatic inhibition during behavior.
    Dudok B, Klein PM, Hwaun E, Lee BR, Yao Z, Fong O, Bowler JC, Terada S, Sparks FT, Szabo GG, Farrell JS, Berg J, Daigle TL, Tasic B, Dimidschstein J, Fishell G, Losonczy A, Zeng H, Soltesz I. Dudok B, et al. Neuron. 2021 Mar 17;109(6):997-1012.e9. doi: 10.1016/j.neuron.2021.01.003. Epub 2021 Feb 1. Neuron. 2021. PMID: 33529646 Free PMC article.

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