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. 2022 Feb;59(2):200-208.
doi: 10.1177/10556656211000551. Epub 2021 Mar 19.

Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation

Alejandro Silva Espinosa  1 , Julio Cesar Martinez  1 , Yubahhaline Molina  1 , María Alejandra Bermúdez Gordillo  1 , Daniel Ramos Hernández  1 , Daniela Zárate Rivera  1 , Blanka Pacheco Olmos  1 , Nathaly Ramírez  1 , Liliana Arias  1 , Andres Zarate  1 , Q Diana Marcela Diaz  1 , Andrew Collins  2 , Álvaro Mauricio Herrera Cepeda  3 , Ignacio Briceño Balcazar  1
Affiliations

Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation

Alejandro Silva Espinosa et al. Cleft Palate Craniofac J. 2022 Feb.

Abstract

Objective: To describe the population of patients with cleft lip and/or palate (CL/P) in terms of cleft phenotypes, gender, age, ethnic group, family history, clinical presentation (syndromic vs nonsyndromic), some environmental and behavioral factors, and some clinical features.

Design: Descriptive retrospective study.

Setting: Patients attending the genetics counseling practice in Operation Smile Foundation, Bogotá, Colombia, for over 8 years.

Participants: No screening was conducted. All patients requiring clinical genetics assessment in Operation Smile Foundation were included in the study.

Results: Left cleft lip and palate (CLP) and nonsyndromic forms were the most frequent types of malformations in this population. Psychomotor retardation and heart disease were the most frequent comorbidities in these patients. A low proportion of mothers exposed to passive smoking during pregnancy was observed and low birth weight accounted for an important number of cases. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CLP in this population.

Conclusions: In this study, the most frequent type of CL/P was the nonsyndromic complete left CLP. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CL/P in this population.

Keywords: epidemiology; maternal factors; nonsyndromic clefting.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Agbenorku P. Orofacial clefts: a worldwide review of the problem. ISRN Plastic Surg. 2013;2013(Article ID 348465):1–7. doi:10.5402/2013/348465
    1. Alfwaress FSD, Khwaileh FA, Rawashdeh MA, Alomari MA, Nazzal MS. Cleft lip and palate: demographic patterns and the associated communication disorders. J Craniofac Surg. 2017;28(8):2117–2121. doi:10.1097/SCS.0000000000003984 - PubMed
    1. AlHammad Z, Suliman I, Alotaibi S, Alnofaie H, Alsaadi W, Alhusseini S, Aldakheel G, Alsubaie N. The prevalence of non-syndromic orofacial clefts and associated congenital heart diseases of a tertiary hospital in Riyadh, Saudi Arabia. Saudi Dental J. 2020. doi:10.1016/j.sdentj.2019.12.002 - PMC - PubMed
    1. Arias L, Briceño I, Lozano JM, Collins A, Uricoechea D. Aspectos clínicos asociados a fisuras orofaciales en una población Colombiana. Colombia Med. 2015;46(4):162–167.
    1. Aschard H. A perspective on interaction effects in genetic association studies. Genet Epidemiol. 2016;40(8):678–688. doi:10.1002/gepi.21989 - PMC - PubMed

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