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. 2021 Mar 18;21(1):92.
doi: 10.1186/s12890-021-01429-2.

Effect of periodontal therapy on COPD outcomes: a systematic review

Ioulianos Apessos  1   2 , Athanasios Voulgaris  3   4 , Michalis Agrafiotis  5 , Dimitrios Andreadis  6 , Paschalis Steiropoulos  3   4
Affiliations

Effect of periodontal therapy on COPD outcomes: a systematic review

Ioulianos Apessos et al. BMC Pulm Med. .

Abstract

Background: Latest evidence suggests that periodontitis is prevalent among patients with chronic obstructive pulmonary disease (COPD), while recent studies have also reported a potential benefit of periodontal treatment on several COPD outcomes. This systematic review aims to determine the impact of periodontal treatment on exacerbation rate, lung function and quality of life of COPD patients.

Methods: A systematic search of electronic databases of PubMed, Scopus, Virtual Health Library, ScienceDirect, Wiley Online Library, Web of Science, ProQuest Dissertation and Theses Global and Google Scholar was conducted. Search restricted to studies involving human subjects which were published from January 2000 to March 2020 in English language. Distiller Systematic Review software was used for data management. Risk of bias was assessed using Risk of Bias 2 (RoB2) and Risk of Bias for non-randomized studies of intervention (ROBINS-I) tools. Overall quality of evidence was judged based on Grading of Recommendations Assessment, Development and Evaluation working group methodology.

Results: Out of 1442 articles retrieved, 7 full text articles were included in the review. Limited evidence suggests that periodontal treatment in patients with COPD and periodontitis is associated with reduced exacerbation frequency and a slower lung function decline rate, while its effects on quality of life remain unclear. In addition, periodontal treatment in COPD is associated with lower hospitalization rates and reduced all-cause mortality. Significant methodological differences were noted amongst included studies, while very low-to-moderate overall quality of evidence was demonstrated.

Conclusions: Although it is reasonable to advise COPD patients not to neglect their dental health, further studies are warranted to determine the role of periodontal therapy on COPD clinical outcomes.

Trial registration: PROSPERO 2020 (CRD42020158481). https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020158481.

Keywords: COPD exacerbation; Chronic obstructive pulmonary disease; Oral health; Periodontal therapy; Systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Prisma flow diagram
Fig. 2
Fig. 2
Risk of bias assessment for randomized trials (RoB2)
Fig. 3
Fig. 3
Risk of bias assessment for non-randomized studies (ROBINS-I)
See this image and copyright information in PMC

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References

    1. Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med. 2017;195(5):557–582. - PubMed
    1. Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3(11):e442. - PMC - PubMed
    1. Wedzicha JA, Seemungal TAR. COPD exacerbations: defining their cause and prevention. Lancet Lond Engl. 2007;370(9589):786–796. - PMC - PubMed
    1. Rubinsztajn R, Przybyłowski T, Maskey-Warzechowska M, Karwat K, Chazan R. Exacerbations of chronic obstructive pulmonary disease and quality of life of patients. Adv Exp Med Biol. 2016;884:69–74. - PubMed
    1. Smith MC, Wrobel JP. Epidemiology and clinical impact of major comorbidities in patients with COPD. Int J Chron Obstruct Pulmon Dis. 2014;9:871–888. - PMC - PubMed

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