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. 2021 Jun;42(6):426-428.
doi: 10.1016/j.tips.2021.03.001. Epub 2021 Mar 15.

Efflux Limits Tumor Drug Delivery Despite Disrupted BBB

Jessica I Griffith  1 , Jann N Sarkaria  2 , William F Elmquist  3
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Efflux Limits Tumor Drug Delivery Despite Disrupted BBB

Jessica I Griffith et al. Trends Pharmacol Sci. 2021 Jun.

Abstract

Apparent blood-brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al. demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain.

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