Hypoglycemia in mitochondrial disorders

Myla Ashfaq¹, Allison R Moats², Hope Northrup¹, Claire N Singletary³, S Shahrukh Hashmi⁴, Mary Kay Koenig⁵, Michael B Bagg⁶, David Rodriguez-Buritica⁷

Affiliations

¹ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
² The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
³ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
⁴ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Pediatrics, Pediatric Research Center, McGovern Medical School at The University of Texas Health Center at Houston, Houston, TX, USA.
⁵ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
⁶ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
⁷ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: David.F.RodriguezBuritica@uth.tmc.edu.

PMID: 33737013
DOI: 10.1016/j.mito.2021.03.002

Hypoglycemia in mitochondrial disorders

Myla Ashfaq et al. Mitochondrion. 2021 May.

. 2021 May:58:179-183.

doi: 10.1016/j.mito.2021.03.002. Epub 2021 Mar 16.

Authors

Myla Ashfaq¹, Allison R Moats², Hope Northrup¹, Claire N Singletary³, S Shahrukh Hashmi⁴, Mary Kay Koenig⁵, Michael B Bagg⁶, David Rodriguez-Buritica⁷

Affiliations

¹ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
² The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
³ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
⁴ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Pediatrics, Pediatric Research Center, McGovern Medical School at The University of Texas Health Center at Houston, Houston, TX, USA.
⁵ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
⁶ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
⁷ McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: David.F.RodriguezBuritica@uth.tmc.edu.

PMID: 33737013
DOI: 10.1016/j.mito.2021.03.002

Abstract

Diabetes and hyperglycemia are common features of mitochondrial disorders. This study investigates the frequency of non-iatrogenic hypoglycemia in individuals with these disorders. Of 116 patients, 22 (18.97%) experienced at least two episodes of hypoglycemia. This rate is significantly higher (p < 0.05) than the 6% seen in the non-diabetic, general population. Neonatal readings were 30 mg/dL lower than non-neonatal readings. As hypoglycemia appears to occur frequently in individuals with mitochondrial disorders, with lower blood glucose levels in the neonatal period, early and continued monitoring of blood glucose is necessary. Also, mitochondrial disorders should be considered in cases of recurrent hypoglycemia.

Keywords: Glucose level; Hyperglycemia; Hypoglycemia; Mitochondrial disorder.

Published by Elsevier B.V.

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Hypoglycemia in mitochondrial disorders

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Hypoglycemia in mitochondrial disorders

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Abstract

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