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Meta-Analysis
. 2021 Jun;30(6):1048-1062.
doi: 10.1158/1055-9965.EPI-20-1029. Epub 2021 Mar 18.

Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis

Tyler J Bruinsma  1 , Anne-Marie Dyer  1   2 , Connie J Rogers  3   4   5 , Kathryn H Schmitz  1   2   4 , Kathleen M Sturgeon  6   2   4
Affiliations
Meta-Analysis

Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis

Tyler J Bruinsma et al. Cancer Epidemiol Biomarkers Prev. 2021 Jun.

Abstract

Background: Adiponectin, leptin, and pro- and anti-inflammatory cytokines are implicated in breast cancer risk and recurrence. Weight loss, via the dynamic interplay of energy balance through exercise and/or caloric restriction, decreases risk of breast cancer recurrence.

Methods: We investigated the effects of lifestyle modifications (exercise only, or combined caloric restriction and exercise) on adipokines, IL2, IL6, IL8, IL10, C-reactive protein (CRP), and TNFα biomarkers in breast cancer survivors. Searches were completed in June and July of 2019 to identify randomized controlled trials that met inclusion criteria. Weighted mean difference was calculated using random- or fixed-effects models based on the heterogeneity of the studies.

Results: 2501 records were identified, with 30 ultimately meeting inclusion criteria of the systematic review; 21 studies provided data suitable for meta-analysis. We observed leptin levels were significantly reduced in the exercise-only group compared with sedentary control [WMD -5.66; 95% confidence interval (CI), -11.0 to -0.33; P = 0.04].

Conclusions: Leptin may be a primary mediator of exercise-induced improvements in breast cancer recurrence.

Impact: This is the first review and meta-analysis to examine combined exercise and caloric restriction programs in breast cancer survivors. Future studies should further examine combined programs and their efficacy for altering leptin.

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Conflict of interest statement

Conflict of Interest: The authors declare no potential conflicts of interest.

Figures

Figure 1:
Figure 1:
Flow chart of search strategy. The approach to identify eligible studies of inflammatory biomarkers in breast cancer survivors before and following an exercise only intervention, or, combined caloric restriction and exercise intervention, is presented.
Figure 2:
Figure 2:
Forest plots of change in adipokine levels following exercise only or combination interventions. Response of leptin to exercise interventions (A) and combined (weight loss + exercise) interventions (B) are presented. Response of adipokine to exercise interventions (C) and combined interventions (D) are also displayed. SD, standard deviation; WMD, weighted mean difference; CI, confidence interval.
Figure 3:
Figure 3:
Forest plots of change in CRP and IL-6 levels following exercise only or combination interventions. Response of CRP to exercise interventions (A) and combined (weight loss + exercise) interventions (B) are presented. Response of IL-6 to exercise interventions (C) and combined interventions (D) are also displayed. SD, standard deviation; WMD, weighted mean difference; CI, confidence interval.
Figure 4:
Figure 4:
Forest plots of change in TNF-α and IL-8 levels following exercise only or combination interventions. Response of TNF-α to exercise interventions (A) and combined (weight loss + exercise) interventions (B) are presented. Response of IL-8 to exercise interventions (C) and combined interventions (D) are also displayed. SD, standard deviation; WMD, weighted mean difference; CI, confidence interval.
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