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Review
. 2021 Feb;12(1):7-19.
doi: 10.14740/wjon1349. Epub 2021 Feb 24.

Cutaneous Malignant Melanoma: A Review of Early Diagnosis and Management

Piyu Parth Naik  1
Affiliations
Review

Cutaneous Malignant Melanoma: A Review of Early Diagnosis and Management

Piyu Parth Naik. World J Oncol. 2021 Feb.

Abstract

Cutaneous melanoma (CM) is a malignant tumor formed from pigment-producing cells called melanocytes. It is one of the most aggressive and fatal forms of skin malignancy. In the last decades, CM's incidence has gradually risen, with 351,880 new cases in 2015. Since the 1960s, its incidence has increased steadily, in 2019, with approximately 96,000 new cases. A greater understanding of early diagnosis and management of CM is urgently needed because of the high mortality rates due to metastatic melanoma. Timely detection of melanoma is crucial for successful treatment, but diagnosis with histopathology may also pose a significant challenge to this objective. Early diagnosis and management are essential and contribute to better survival rates of the patient. To better control this malignancy, such information is expected to be particularly useful in the early detection of possible metastatic lesions and the development of new therapeutic approaches. This article reviews the available information on the early diagnosis and management of CM and discusses such information's potential in facilitating the future prospective.

Keywords: Cutaneous melanoma; Early diagnosis; Malignant melanoma; Management; Mortality; Tumor.

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Conflict of interest statement

None to declare.

References

    1. Leonardi GC, Falzone L, Salemi R, Zanghi A, Spandidos DA, McCubrey JA, Candido S. et al. Cutaneous melanoma: From pathogenesis to therapy (Review) Int J Oncol. 2018;52(4):1071–1080. doi: 10.3892/ijo.2018.4287. - DOI - PMC - PubMed
    1. Orzan OA, Sandru A, Jecan CR. Controversies in the diagnosis and treatment of early cutaneous melanoma. J Med Life. 2015;8(2):132–141. - PMC - PubMed
    1. Lesage C, Barbe C, Le Clainche A, Lesage FX, Bernard P, Grange F. Sex-related location of head and neck melanoma strongly argues for a major role of sun exposure in cars and photoprotection by hair. J Invest Dermatol. 2013;133(5):1205–1211. doi: 10.1038/jid.2012.405. - DOI - PubMed
    1. Caini S, Gandini S, Sera F, Raimondi S, Fargnoli MC, Boniol M, Armstrong BK. Meta-analysis of risk factors for cutaneous melanoma according to anatomical site and clinico-pathological variant. Eur J Cancer. 2009;45(17):3054–3063. doi: 10.1016/j.ejca.2009.05.009. - DOI - PubMed
    1. Burns D, George J, Aucoin D, Bower J, Burrell S, Gilbert R, Bower N. The pathogenesis and clinical management of cutaneous melanoma: an evidence-based review. J Med Imaging Radiat Sci. 2019;50(3):460–469. doi: 10.1016/j.jmir.2019.05.001. e461. - DOI - PubMed

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