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. 2021 Oct 1;23(10):1765-1776.
doi: 10.1093/neuonc/noab067.

The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)

Fabio Girardi  1   2 , Brian Rous  3 , Charles A Stiller  3 , Gemma Gatta  4 , Naomi Fersht  2 , Hans H Storm  5 , Jessica R Rodrigues  6 , Christian Herrmann  7 , Rafael Marcos-Gragera  8 , Rafael Peris-Bonet  9 , Mikhail Valkov  10 , Hannah K Weir  11 , Ryan R Woods  12 , Hui You  13 , Patricia A Cueva  14 , Prithwish De  15 , Veronica Di Carlo  1 , Tom Børge Johannesen  16 , Carlos A Lima  17 , Charles F Lynch  18 , Michel P Coleman  1   2 , Claudia Allemani  1 ; CONCORD Working Group
Collaborators, Affiliations

The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)

Fabio Girardi et al. Neuro Oncol. .

Abstract

Background: Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America.

Methods: The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014.

Results: Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults.

Conclusions: To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.

Keywords: International Classification of Diseases; epidemiological study; health care disparities; histology; population-based cancer registries; primary brain tumor.

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Figures

Fig. 1
Fig. 1
Histology distribution (%) by country, children (0-14 years), 2005-2009. Numbers in brackets are counts (all brain tumors combined). *Data with 100% coverage of the national population.
Fig. 2
Fig. 2
Histology distribution (%) by country, adults (15-99 years), 2005-2009. Numbers in brackets are counts (all brain tumors combined). *Data with 100% coverage of the national population.
See this image and copyright information in PMC

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References

    1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. WHO Classification of Tumours of the Central Nervous System. 4th ed. Geneva: WHO (World Health Organization); 2007.
    1. International Agency for Research on Cancer. Global cancer observatory; Cancer Today; 2018. http://gco.iarc.fr/today/home. Accessed September 1, 2020.
    1. Fidler MM, Gupta S, Soerjomataram I, Ferlay J, Steliarova-Foucher E, Bray F. Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study. Lancet Oncol. 2017;18(12):1579–1589. - PubMed
    1. Bhakta N, Force LM, Allemani C, et al. . Childhood cancer burden: a review of global estimates. Lancet Oncol. 2019;20(1):e42–e53. - PubMed
    1. Rodriguez-Galindo C, Friedrich P, Alcasabas P, et al. . Toward the cure of all children with cancer through collaborative efforts: pediatric oncology as a global challenge. J Clin Oncol. 2015;33(27):3065–3073. - PMC - PubMed

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