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. 2021 Oct;147(10):3091-3097.
doi: 10.1007/s00432-021-03576-9. Epub 2021 Mar 18.

Epidemiology and prognosis of parathyroid carcinoma: real-world data using nationwide cohort

Sung Hye Kong  1   2 , Jung Hee Kim  1   2 , Man Young Park  3 , Sang Wan Kim  4   5 , Chan Soo Shin  1   2
Affiliations

Epidemiology and prognosis of parathyroid carcinoma: real-world data using nationwide cohort

Sung Hye Kong et al. J Cancer Res Clin Oncol. 2021 Oct.

Abstract

Purpose: Parathyroid carcinoma (PC) is an exceedingly rare endocrine malignancy with a poor prognosis. Due to the rarity, the natural course and prognostic factors of the disease are yet unclear. Therefore, we aimed to identify the incidence, prognosis, and prognostic factors of PC in the nationwide cohort study.

Methods: The study is a nationwide study using the National Health Insurance Services database in Korea from 2002 to 2017. PC was defined as patients with ICD-10 code of PC and a procedural code for parathyroidectomy.

Results: From 2002 to 2017, 255 patients were diagnosed with PC whose mean age was 53.2 years, and 155 (60.2%) were women. The crude and age-standardized incidence were 10.2 and 6.6/10,000,000 person-year in 2016, rising from 4.1 and 3.8/10,000,000 person-year in 2003 (p < 0.001), respectively. The 5- and 10-year survival rates were 86.5 and 72.9%, respectively. In survival analysis, age over 50 years, thyroidectomy at the initial surgery, and reoperation had increased risk of mortality with HRs of 4.83 (95% CI 1.47-15.90), and 4.21 (95% CI 1.60-11.08), and 1.05 (95% CI 1.02-1.08) in multivariate analysis, respectively.

Conclusion: Incidence of PC has been rising over time, similar to the trends in Western countries. The prognostic factors for mortality were old age, parathyroidectomy alone, and recurrence, emphasizing the importance of preoperative suspicion of the disease. The study is clinically meaningful in the first Asian nationwide study to reveal the natural course of PC.

Keywords: Cohort; Nationwide; Parathyroid carcinoma; Prognosis.

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Conflict of interest statement

SHK, JHK, MYP, SWK, and CSS declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
a Incidence and b age and gender distribution of parathyroid carcinoma
Fig. 2
Fig. 2
Kaplan–Meier curve illustrating survival probability according to (a) the initial surgical extent and (b) age. HR hazard ratio, CI confidence interval
See this image and copyright information in PMC

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References

    1. Brown S et al (2011) Parathyroid carcinoma: increasing incidence and changing presentation. ANZ J Surg 81:528–532. 10.1111/j.1445-2197.2010.05594.x - PubMed
    1. Busaidy NL et al (2004) Parathyroid carcinoma: a 22-year experience. Head Neck 26:716–726. 10.1002/hed.20049 - PubMed
    1. DeLellis RA (2004) Pathology and genetics of tumours of endocrine organs, vol 8. IARC, Lyon
    1. Griebeler ML, Kearns AE, Ryu E, Hathcock MA, Melton LJ 3rd, Wermers RA (2015) Secular trends in the incidence of primary hyperparathyroidism over five decades (1965–2010). Bone 73:1–7. 10.1016/j.bone.2014.12.003 - PMC - PubMed
    1. Harari A et al (2011) Parathyroid carcinoma: a 43-year outcome and survival analysis. J Clin Endocrinol Metab 96:3679–3686. 10.1210/jc.2011-1571 - PubMed

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