Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep;31(9):7121-7131.
doi: 10.1007/s00330-021-07835-8. Epub 2021 Mar 18.

Indication of the prognosis of pulmonary hypertension by using CMR function parameters

Wen Ren #  1   2 , Jing-Jing Guo #  3 , Fan Yang #  2 , Zhen-Wen Yang  4 , Tie-Lian Yu  2 , Yuan-Lin Deng  2 , Zhang Zhang  5 , Dong Li  6
Affiliations

Indication of the prognosis of pulmonary hypertension by using CMR function parameters

Wen Ren et al. Eur Radiol. 2021 Sep.

Abstract

Objective: This study aimed to compare the cardiac function among different sub-types of pulmonary hypertension (PH) and to explore the independent predictors of major adverse cardiovascular events (MACE).

Methods: Eighty-seven PH patients diagnosed by right heart catheterization (RHC) were recruited. Patients underwent cardiac magnetic resonance (CMR) and RHC examination within 2 weeks. The CMR images were analyzed to calculate the cardiac functional parameters including right ventricle (RV) and left ventricle (LV) end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume index (SVI), ejection fraction (EF), tricuspid annular plane systolic excursion (TAPSE), and myocardial mass (MM). The median follow-up time was 46.5 months (interquartile range: 26-65.5 months), and the endpoints were the occurrence of MACE.

Results: RVEDVI, LVEDVI, and LVESVI were higher in congenital heart disease-related PH (CHD-PH) than in other sub-types (p < 0.05). RVMM, RVSVI, and RVCI were highest in CHD-PH. There was no significant difference in the prognosis among different sub-types (p > 0.05). Comparing with the non-MACE group, RVEF, TAPSE, and LVSVI significantly decreased in the MACE group, while the RVESVI significantly increased (p < 0.05). TAPSE ≤ 15.65 mm and LVSVI ≤ 30.27 mL/m2 were significant independent predictors of prognosis in PH patients.

Conclusion: CHD-PH had a higher RV function reserve but lowest LVEF comparing to other subgroups. TAPSE and LVSVI could contribute to the prediction of MACE in PH patients.

Key points: • CMR imaging is a noninvasive and accurate tool to assess ventricular function. • CHD-PH had higher RV function reserve but lowest LVEF. • TAPSE and LVSVI could contribute to the prediction of MACE in PH patients.

Keywords: Follow-up studies; Heart defects, congenital; Hypertension, pulmonary; Magnetic resonance imaging; Prognosis.

PubMed Disclaimer

References

    1. Aluja Jaramillo F, Gutierrez FR, Diaz Telli FG, Yevenes Aravena S, Javidan-Nejad C, Bhalla S (2018) Approach to pulmonary hypertension: from CT to clinical diagnosis. Radiographics 38:357–373 - DOI
    1. Humbert M (2010) Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: pathophysiology. Eur Respir Rev 19:59–63 - DOI
    1. Escribano-Subias P, Blanco I, López-Meseguer M et al (2012) Survival in pulmonary hypertension in Spain: insights from the Spanish registry. Eur Respir J 40:596–603 - DOI
    1. Chung WJ, Park YB, Jeon CH et al (2015) Baseline characteristics of the Korean Registry of Pulmonary Arterial Hypertension. J Korean Med Sci 30:1429–1438 - DOI
    1. Zhang Z, Wang M, Yang Z et al (2017) Noninvasive prediction of pulmonary artery pressure and vascular resistance by using cardiac magnetic resonance indices. Int J Cardiol 227:915–922 - DOI

MeSH terms

LinkOut - more resources