Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Apr;81(5):611-614.
doi: 10.1007/s40265-021-01494-1. Epub 2021 Mar 18.

Comment on "Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update"

Udo Bonnet  1   2 , Heath McAnally  3   4 , Norbert Scherbaum  5
Affiliations
Comment

Comment on "Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update"

Udo Bonnet et al. Drugs. 2021 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest related to this letter, except that they themselves had carried out two reviews about the highly debated topic of pregabalin´s and gabapentin´s harms and addiction [11, 22]. Furthermore, Norbert Scherbaum received honoraria for several activities (advisory boards, lectures, manuscripts) from AbbVie, Camurus, Hexal, Janssen-Cilag, MSD, Medice, Mundipharma, Reckitt-Benckiser/Indivior, and Sanofi-Aventis. During the last 3 years he participated in clinical trials financed by the pharmaceutical industry.

Figures

Fig. 1
Fig. 1
Scatter diagram showing the assessment of the average overall harm of a substance in relation to its average benefit assessment (category: “no/little benefit”). Two groups are already visually demarcated (lower left square: prescription drugs; upper right square: traditional drugs of abuse except of cannabis and ketamine). Assessments were performed by 101 German physicians both specialized in addiction medicine and working for a median of 15 years in the tertiary care of patients with substance-use disorders [9, 10]. Note that this assessment is not representative for countries dealing with an opioid epidemic (where the potential synergy/opioid-sparing features of gabapentanoids (GPs) or other CNS depressants might be more salient)
See this image and copyright information in PMC

Comment in

Comment on

References

    1. Evoy KE, Sadrameli S, Contreras J, Covvey JR, Peckham AM, Morrison MD. Abuse and misuse of pregabalin and gabapentin: a systematic review update. Drugs. 2020 doi: 10.1007/s40265-020-01432-7. - DOI - PubMed
    1. Oxford Centre for evidence-based medicine: levels of evidence. 2009. https://www.cebm.ox.ac.uk/resources/levels-of-evidence/oxford-centre-for.... Accessed 1 Jan 2021.
    1. Thiese MS. Observational and interventional study design types; an overview. Biochem Med (Zagreb). 2014;24(2):199–210. doi: 10.11613/BM.2014.022. - DOI - PMC - PubMed
    1. Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51(6):1173–1182. doi: 10.1037//0022-3514.51.6.1173. - DOI - PubMed
    1. Hayes AF. Mediation, moderation, and conditional process analysis. 2. New York: Guilford Press; 2018.

LinkOut - more resources