Clinical Trial

. 2021 May;52(5):1534-1544.

doi: 10.1161/STROKEAHA.121.034436. Epub 2021 Mar 19.

New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial

Rishi Gupta¹, Jeffrey L Saver², Elad Levy³, Osama O Zaidat³, Dileep Yavagal⁴, David S Liebeskind², Ahmad Khaldi¹, Bradley Gross⁵, Michael Lang¹, Sandra Narayanan⁶, Brian Jankowitz⁷, Kenneth Snyder⁸, Adnan Siddiqui⁸, Jason Davies⁸, Eugene Lin³, Ameer Hassan⁹, Ricardo Hanel¹⁰, Amin Aghaebrahim¹⁰, Ritesh Kaushal¹¹, Ali Malek¹¹, Nils Mueller-Kronast¹¹, Robert Starke¹², Hormozd Bozorgchami¹³, Gary Nesbit¹³, Masahiro Horikawa¹³, Ryan Priest¹³, Jesse Liu¹³, Ronald F Budzik¹⁴, Peter Pema¹⁴, Nirav Vora¹⁴, M Asif Taqi¹⁵, Edgar Samaniego¹⁶, Qingliang Tony Wang¹⁷, Erez Nossek¹⁸, Guilherme Dabus¹⁹, Italo Linfante¹⁹, Ajit Puri²⁰, Eitan Abergel²¹, Sidney Starkman²², Satoshi Tateshima²³, Ashutosh P Jadhav²⁴; TIGER Trial Investigators

Affiliations

¹ Wellstar Medical Group, Department of Neurosurgery, Wellstar Health System Kennestone Hospital Marietta, GA (R.G., A.K.).
² Department of Neurology and Comprehensive Stroke Center, University of California Los Angeles (J.L.S., D.S.L.).
³ Departments of Endovascular Neurosurgery and Stroke, St. Vincent Mercy Medical Center, Toledo, OH (E.L., O.O.Z.).
⁴ Department of Neurology (D.Y.), University of Miami School of Medicine, FL.
⁵ Department of Neurosurgery, Stroke Institute, University of Pittsburgh Medical Center, PA (B.G., M.L.).
⁶ Neurology, University of Pittsburgh Medical Center, PA (S.N.).
⁷ Department of Neurosurgery, Cooper University Health Care, Camden, NJ (B.J.).
⁸ Department of Neurosurgery, State University of New York at Buffalo (K.S., A.S.. J.D.).
⁹ Department of Neurology, Valley Baptist Medical Center, Harlingen, TX (A.H.).
¹⁰ Stroke and Cerebrovascular Surgery, Lyerly Neurosurgery/Baptist Neurological Institute, Jacksonville, FL (R.H., A.A.).
¹¹ Advanced Neuroscience Network/Tenet South Florida, Delray Beach (R.K., A.M., N.M.-K.).
¹² Department of Neurosurgery (R.S.), University of Miami School of Medicine, FL.
¹³ Oregon Health and Science University, Portland (H.B., G.N., M.H., R.P., J.L.).
¹⁴ Department of Radiology, Riverside Radiology and Interventional Associates, Columbus, OH (R.F.B., P.P., N.V.).
¹⁵ Vascular Neurology of Southern California, Los Robles Hospital, Thousand Oaks (M.A.T.).
¹⁶ Departments of Neurology, Neurosurgery and Radiology University of Iowa Hospitals and Clinics, Iowa City (E.S.).
¹⁷ Departments of Neurology, Surgery/Neurosurgery, and Comprehensive Stroke Center, Maimonides Medical Center/SUNY Downstate Health Sciences University, Brooklyn, NY (Q.T.W.).
¹⁸ Department of Neurosurgery, New York University Medical School (E.N.).
¹⁹ Department of Neurointerventional Surgery, Baptist Cardiac and Vascular Institute, Miami, FL (G.D., I.L.).
²⁰ Department of Radiology, University of Massachusetts Medical School, Worcester (A.P.).
²¹ Department of Neuroradiology, Rambam Health Care, Haifa, Israel (E.A.).
²² Department of Emergency Medicine (S.S.), University of California Los Angeles.
²³ Department of Radiology and Neurosurgery (S.T.), University of California Los Angeles.
²⁴ Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ (A.P.J.).

PMID: 33739136
PMCID: PMC8078128
DOI: 10.1161/STROKEAHA.121.034436

Clinical Trial

New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial

Rishi Gupta et al. Stroke. 2021 May.

. 2021 May;52(5):1534-1544.

doi: 10.1161/STROKEAHA.121.034436. Epub 2021 Mar 19.

Authors

Affiliations

¹ Wellstar Medical Group, Department of Neurosurgery, Wellstar Health System Kennestone Hospital Marietta, GA (R.G., A.K.).
² Department of Neurology and Comprehensive Stroke Center, University of California Los Angeles (J.L.S., D.S.L.).
³ Departments of Endovascular Neurosurgery and Stroke, St. Vincent Mercy Medical Center, Toledo, OH (E.L., O.O.Z.).
⁴ Department of Neurology (D.Y.), University of Miami School of Medicine, FL.
⁵ Department of Neurosurgery, Stroke Institute, University of Pittsburgh Medical Center, PA (B.G., M.L.).
⁶ Neurology, University of Pittsburgh Medical Center, PA (S.N.).
⁷ Department of Neurosurgery, Cooper University Health Care, Camden, NJ (B.J.).
⁸ Department of Neurosurgery, State University of New York at Buffalo (K.S., A.S.. J.D.).
⁹ Department of Neurology, Valley Baptist Medical Center, Harlingen, TX (A.H.).
¹⁰ Stroke and Cerebrovascular Surgery, Lyerly Neurosurgery/Baptist Neurological Institute, Jacksonville, FL (R.H., A.A.).
¹¹ Advanced Neuroscience Network/Tenet South Florida, Delray Beach (R.K., A.M., N.M.-K.).
¹² Department of Neurosurgery (R.S.), University of Miami School of Medicine, FL.
¹³ Oregon Health and Science University, Portland (H.B., G.N., M.H., R.P., J.L.).
¹⁴ Department of Radiology, Riverside Radiology and Interventional Associates, Columbus, OH (R.F.B., P.P., N.V.).
¹⁵ Vascular Neurology of Southern California, Los Robles Hospital, Thousand Oaks (M.A.T.).
¹⁶ Departments of Neurology, Neurosurgery and Radiology University of Iowa Hospitals and Clinics, Iowa City (E.S.).
¹⁷ Departments of Neurology, Surgery/Neurosurgery, and Comprehensive Stroke Center, Maimonides Medical Center/SUNY Downstate Health Sciences University, Brooklyn, NY (Q.T.W.).
¹⁸ Department of Neurosurgery, New York University Medical School (E.N.).
¹⁹ Department of Neurointerventional Surgery, Baptist Cardiac and Vascular Institute, Miami, FL (G.D., I.L.).
²⁰ Department of Radiology, University of Massachusetts Medical School, Worcester (A.P.).
²¹ Department of Neuroradiology, Rambam Health Care, Haifa, Israel (E.A.).
²² Department of Emergency Medicine (S.S.), University of California Los Angeles.
²³ Department of Radiology and Neurosurgery (S.T.), University of California Los Angeles.
²⁴ Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ (A.P.J.).

PMID: 33739136
PMCID: PMC8078128
DOI: 10.1161/STROKEAHA.121.034436

Erratum in

Correction to: A New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter Tiger Trial.
[No authors listed] [No authors listed] Stroke. 2021 Jun;52(6):e310. doi: 10.1161/STR.0000000000000376. Epub 2021 May 24. Stroke. 2021. PMID: 34029155 Free PMC article. No abstract available.

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT03474549.

Keywords: goal; intracranial hemorrhage; laboratories; reperfusion; stent.

PubMed Disclaimer

Figures

**Figure 1.**
**Tigertriever device and chart of patient flow through study.** A, Tigertriever device including external handle for the operator to control the degree of expansion of the stent retriever. Fine wire mesh mounted on a flexible shaft. The design of the wire mesh (magnified view) is optimized to penetrate the clot and encapsulate it during retrieval. B, Patient screening, enrollment, treatment, and follow-up. ICH indicates intracranial hemorrhage; LVO, large vessel occlusion; mRS, modified Rankin Scale; and NIHSS, National Institutes of Health Stroke Scale.

**Figure 2.**
**Reperfusion and functional outcomes in main-study phase of TIGER trial (Treatment With Intent to Generate Endovascular Reperfusion).** A, Reperfusion degree after first pass, after up to 3 Tigertriever passes, and after rescue therapy. B, Distribution of 90-d global disability outcomes on the modified Rankin Scale (mRS). mRS was available from 114 patients out of the 117 of the main-study group. mTICI indicates modified Thrombolysis in Cerebral Ischemia.

See this image and copyright information in PMC

References

1. Berkhemer OA, Fransen PS, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, Schonewille WJ, Vos JA, Nederkoorn PJ, Wermer MJ, et al. ; MR CLEAN Investigators. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372:11–20. doi: 10.1056/NEJMoa1411587 - PubMed
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1. Campbell BC, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, Yan B, Dowling RJ, Parsons MW, Oxley TJ, et al. ; EXTEND-IA Investigators. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372:1009–1018. doi: 10.1056/NEJMoa1414792 - PubMed

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New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial

Affiliations

New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial

Authors

Affiliations

Erratum in

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LinkOut - more resources

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