. 2021 Nov 16;224(9):1570-1580.

doi: 10.1093/infdis/jiab151.

Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers

Jeanne Goupil de Bouillé^{1

2}, Corinne Vigouroux^{3

4}, Lorraine Plessis², Mathilde Ghislain², Jean-Paul Teglas², Faroudy Boufassa², Cécile Goujard^{2

5}, Dorothée Vignes⁶, Olivier Bouchaud^{1

7}, Dominique Salmon⁸, Laurence Meyer^{2

9}, Sophie Abgrall^{2

6}; ANRS CO9-COPANA study group

Collaborators, Affiliations

Collaborators

ANRS CO9-COPANA study group:
O B, F B, Robert Carlier, Rosemary Dray-Spira, M G, C G, L P, Lucie Marchand, L M, Ventzislava Petrov-Sanchez, L P, Christine Rouzioux, Rémonie Seng, Rodolphe Thiebaut, Jean-Paul Viard, S A, F B, Abdellatif Essabbani, Tatiana Feitoza, C G, Alain-Serge Keita, Rémonie Seng, J P T, Laurent Tran, Soraya Fellahi, Jean-Philippe Bastard, A Simon, D Beniken, P M Girard, Z Ouazene, B Lefebvre, J Lamarque, A Ameur, G Pialoux, J Chas, L Slama, F Z Makhoukhi, P Passe-Courtin, L Gérard, J M Molina, C Lascoux-Combe, J Delgado, S Parlier, J F Bergmann, V Delcey, P Sellier, A Rami, M Parrinello, O B, L Traore, A Benmammar, M Kassim, Y Yazdanpanah, S Matheron, S Lariven, V Joly, C Rioux, F Louni, J Zelie, B Fantin, A Villemant, C Bazin, L Weiss, J Pavie, M Manea, G H Tarnier-Cochin, D S, M P Pietri, J P Viard, A Maignan, M J Dulucq, F Boué, S A, I Kansau, D V, S Poirier, C G, O Lambotte, K Bourdic, J D Lelièvre, C Chesnel, C Duvivier, O Lortholary, F Touam, D Rey, P Fischer, M L Batard And, M Mohseni Zadeh, A Richard, G Blaison, M Martinot, A Pachard, D Neau, S Le Puil, P Morlat, S Caldato, L Bernard, M C Hallouin-Bernard, O Bourgault, C Chirouze, M C Thiebaut-Drobacheff, A Proust, Q Gardiennet, J Reynes, C Crisol, C Tramoni, T May, M P Bouillon, M Delestan, M André, A Meybeck, M C Marien, J Moreau, M J Carmantrand, L Meddeb, I Poizot-Martin, M Guignard, C Blanco Bétancourt, A Ivanova, F Raffi, L Larmetand, H Hue, P Perré, A Pegeot, L Cotte, C Chidiac, S Ogoudjobi, D Makhloufi, S Gibert, A Cabié, S Abel, P Hochedez, F Ronin, A S Batalla, C Cerland, S Pierre-François, B Roze

Affiliations

¹ APHP, Hôpital Avicenne, Service de Maladies Infectieuses et Tropicales, Bobigny, France.
² Université Paris-Saclay, UVSQ, Inserm U1018, CESP, Le Kremlin-Bicêtre, France.
³ AP-HP, Hôpital Saint-Antoine, Centre de Référence des Pathologies Rares de l'Insulino-Sécrétion et de l'Insulino-Sensibilité, Service d'Endocrinologie et Laboratoire Commun de Biologie et Génétique Moléculaires, Paris, France.
⁴ Sorbonne Université, Inserm U938, Centre de Recherche Saint-Antoine, Paris, France.
⁵ AP-HP, Hôpital Bicêtre, Service de Médecine Interne, Le Kremlin-Bicêtre, France.
⁶ AP-HP, Hôpital Béclère, Service de Médecine Interne, Clamart, France.
⁷ Laboratoire Educations et Pratiques de Santé EA 3412, Université Paris 13, Bobigny, France.
⁸ AP-HP, Hôpital Hôtel Dieu, Centre de Diagnostic et de Thérapeutique, Paris, France.
⁹ AP-HP, Hôpital Bicêtre, Service de Santé Publique, Le Kremlin-Bicêtre, France.

PMID: 33740044
DOI: 10.1093/infdis/jiab151

Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers

Jeanne Goupil de Bouillé et al. J Infect Dis. 2021.

. 2021 Nov 16;224(9):1570-1580.

doi: 10.1093/infdis/jiab151.

Authors

Collaborators

ANRS CO9-COPANA study group:
O B, F B, Robert Carlier, Rosemary Dray-Spira, M G, C G, L P, Lucie Marchand, L M, Ventzislava Petrov-Sanchez, L P, Christine Rouzioux, Rémonie Seng, Rodolphe Thiebaut, Jean-Paul Viard, S A, F B, Abdellatif Essabbani, Tatiana Feitoza, C G, Alain-Serge Keita, Rémonie Seng, J P T, Laurent Tran, Soraya Fellahi, Jean-Philippe Bastard, A Simon, D Beniken, P M Girard, Z Ouazene, B Lefebvre, J Lamarque, A Ameur, G Pialoux, J Chas, L Slama, F Z Makhoukhi, P Passe-Courtin, L Gérard, J M Molina, C Lascoux-Combe, J Delgado, S Parlier, J F Bergmann, V Delcey, P Sellier, A Rami, M Parrinello, O B, L Traore, A Benmammar, M Kassim, Y Yazdanpanah, S Matheron, S Lariven, V Joly, C Rioux, F Louni, J Zelie, B Fantin, A Villemant, C Bazin, L Weiss, J Pavie, M Manea, G H Tarnier-Cochin, D S, M P Pietri, J P Viard, A Maignan, M J Dulucq, F Boué, S A, I Kansau, D V, S Poirier, C G, O Lambotte, K Bourdic, J D Lelièvre, C Chesnel, C Duvivier, O Lortholary, F Touam, D Rey, P Fischer, M L Batard And, M Mohseni Zadeh, A Richard, G Blaison, M Martinot, A Pachard, D Neau, S Le Puil, P Morlat, S Caldato, L Bernard, M C Hallouin-Bernard, O Bourgault, C Chirouze, M C Thiebaut-Drobacheff, A Proust, Q Gardiennet, J Reynes, C Crisol, C Tramoni, T May, M P Bouillon, M Delestan, M André, A Meybeck, M C Marien, J Moreau, M J Carmantrand, L Meddeb, I Poizot-Martin, M Guignard, C Blanco Bétancourt, A Ivanova, F Raffi, L Larmetand, H Hue, P Perré, A Pegeot, L Cotte, C Chidiac, S Ogoudjobi, D Makhloufi, S Gibert, A Cabié, S Abel, P Hochedez, F Ronin, A S Batalla, C Cerland, S Pierre-François, B Roze

Affiliations

¹ APHP, Hôpital Avicenne, Service de Maladies Infectieuses et Tropicales, Bobigny, France.
² Université Paris-Saclay, UVSQ, Inserm U1018, CESP, Le Kremlin-Bicêtre, France.
³ AP-HP, Hôpital Saint-Antoine, Centre de Référence des Pathologies Rares de l'Insulino-Sécrétion et de l'Insulino-Sensibilité, Service d'Endocrinologie et Laboratoire Commun de Biologie et Génétique Moléculaires, Paris, France.
⁴ Sorbonne Université, Inserm U938, Centre de Recherche Saint-Antoine, Paris, France.
⁵ AP-HP, Hôpital Bicêtre, Service de Médecine Interne, Le Kremlin-Bicêtre, France.
⁶ AP-HP, Hôpital Béclère, Service de Médecine Interne, Clamart, France.
⁷ Laboratoire Educations et Pratiques de Santé EA 3412, Université Paris 13, Bobigny, France.
⁸ AP-HP, Hôpital Hôtel Dieu, Centre de Diagnostic et de Thérapeutique, Paris, France.
⁹ AP-HP, Hôpital Bicêtre, Service de Santé Publique, Le Kremlin-Bicêtre, France.

PMID: 33740044
DOI: 10.1093/infdis/jiab151

Abstract

Background: We investigated the association between socioclinical, inflammatory, and metabolic markers and weight gain in people with human immunodeficiency virus (HIV) on combination antiretroviral therapy (cART).

Methods: Individuals from the COPANA cohort of normal weight (body mass index [BMI], 18.5-24.9 [ calculated as weight in kilograms divided by height in meters squared) at cART initiation who achieved virological suppression (viral load, <50 copies/mL) and maintained it through 36 months of treatment were selected. Clinical, immunovirological, and socioeconomic data and inflammation (high-sensitivity C-reactive protein, CXCL10, CXCL8, interleukin 6, soluble tumor necrosis factor receptors 1 and 2, soluble CD14, and soluble CD16) and serum metabolic (glucose, insulin, lipid profile, adiponectin, and leptin) markers were assessed. Factors associated with becoming overweight (BMI, 25-29.9) or obese (BMI, ≥30) at 36 months were assessed using multivariate logistic regression models.

Results: After 36 months of cART, 32 of 158 people with HIV (20%) became overweight or obese (21% female; 65% born in France and 23% born in sub-Saharan Africa; median BMI at cART initiation, 22 [interquartile range, 21-23]). After adjustment, higher BMI, originating from sub-Saharan Africa, living in a couple, and higher soluble tumor necrosis factor receptor 2 and lower adiponectin concentrations at cART initiation were associated with becoming overweight or obese.

Conclusion: Weight gain on cART is multifactorial. Special attention should be given to migrants from sub-Saharan Africa. Monocyte activation and adipocyte dysfunction at cART initiation affect weight regulation.

Keywords: HIV; inflammation; metabolic; migrants; obesity; overweight; social; sub-Saharan Africa.

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Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers

Collaborators

Affiliations

Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers

Authors

Collaborators

Affiliations

Abstract

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MeSH terms

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LinkOut - more resources

Full Text Sources

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Medical

Research Materials