Methadone and Ketamine: Boosting Benefits and Still More to Learn
- PMID: 33740051
- PMCID: PMC8044044
- DOI: 10.1097/ALN.0000000000003752
Methadone and Ketamine: Boosting Benefits and Still More to Learn
Comment on
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Perioperative Methadone and Ketamine for Postoperative Pain Control in Spinal Surgical Patients: A Randomized, Double-blind, Placebo-controlled Trial.Anesthesiology. 2021 May 1;134(5):697-708. doi: 10.1097/ALN.0000000000003743. Anesthesiology. 2021. PMID: 33730151 Clinical Trial.
References
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- Gourlay GK, Wilson PR, Glynn CJ: Pharmacodynamics and pharmacokinetics of methadone during the perioperative period. Anesthesiology 1982;57:458–467 - PubMed
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- Murphy GS, Szokol JW: Intraoperative methadone in surgical patients: A review of clinical investigations. Anesthesiology 2019;131:678–692 - PubMed
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- Murphy GS, Avram MJ, Greenberg SB, Shear TD, Deshur MA, Dickerson D, Bilimoria S, Benson J, Maher CE, Trenk GJ, Teister KJ, Szokol JW: Postoperative pain and analgesic requirements in the first year after intraoperative methadone for complex spine and cardiac surgery. Anesthesiology 2020;132:330–342 - PubMed
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