Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021:1316:41-47.
doi: 10.1007/978-981-33-6785-2_3.

Overview: Lipid Metabolism in the Tumor Microenvironment

Kaili Ma  1   2 , Lianjun Zhang  3   4
Affiliations
Review

Overview: Lipid Metabolism in the Tumor Microenvironment

Kaili Ma et al. Adv Exp Med Biol. 2021.

Abstract

The tumor microenvironment represents the dynamic network consisting of tumor cells, stromal cells, and multiple lineages of immune subsets. It is well recognized that metabolic crosstalk within the tumor microenvironment (TME) greatly shapes both the composition and functionality of the infiltrated immune cells and therefore critically regulate the antitumor immunity. In general, most solid tumors are considered as lipid-enriched environment, which is beneficial for tumor cell growth and immune escape. Here we briefly summarize the effects of accumulated lipids on tumor cells and immune cells. We also discuss the possibility of targeting lipid metabolism within the TME and potential strategies for optimizing cancer treatment.

Keywords: Antitumor immunity; Immunosuppression; Lipid metabolism; T cells; Tumor microenvironment.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Egeblad M, et al. Tumors as organs: complex tissues that interface with the entire organism. Dev Cell. 2010;18(6):884–901. - PubMed - PMC - DOI
    1. Reina-Campos M, et al. Metabolism shapes the tumor microenvironment. Curr Opin Cell Biol. 2017;48:47–53. - PubMed - PMC - DOI
    1. Lyssiotis CA, Kimmelman AC. Metabolic interactions in the tumor microenvironment. Trends Cell Biol. 2017;27(11):863–75. - PubMed - PMC - DOI
    1. Binnewies M, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018;24(5):541–50. - PubMed - PMC - DOI
    1. Ma X, et al. Cholesterol induces CD8(+) T cell exhaustion in the tumor microenvironment. Cell Metab. 2019;30(1):143–15.6.e5. - PubMed - PMC - DOI

LinkOut - more resources