Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Mar 18;184(6):1604-1620.
doi: 10.1016/j.cell.2021.02.013.

Antivirals with common targets against highly pathogenic viruses

Lu Lu  1 , Shan Su  1 , Haitao Yang  2 , Shibo Jiang  3
Affiliations
Free article
Review

Antivirals with common targets against highly pathogenic viruses

Lu Lu et al. Cell. .
Free article

Abstract

Historically, emerging viruses appear constantly and have cost millions of human lives. Currently, climate change and intense globalization have created favorable conditions for viral transmission. Therefore, effective antivirals, especially those targeting the conserved protein in multiple unrelated viruses, such as the compounds targeting RNA-dependent RNA polymerase, are urgently needed to combat more emerging and re-emerging viruses in the future. Here we reviewed the development of antivirals with common targets, including those against the same protein across viruses, or the same viral function, to provide clues for development of antivirals for future epidemics.

PubMed Disclaimer

Conflict of interest statement

Declaration of Interests The authors declare that they do not have manifest conflict of interest. S.J. and L.L. have been holding research contracts with Shanxi Jinbo Bio-Pharmaceutical Inc Co. and hold patents covering the peptide-based pan-CoV fusion inhibitors. H.Y. holds patents covering the CoV Mpro inhibitors.

Publication types

MeSH terms

LinkOut - more resources