Comment
doi: 10.1016/j.molcel.2021.02.026.
Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis
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- PMID: 33740472
- DOI: 10.1016/j.molcel.2021.02.026
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Comment
Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis
Mol Cell.
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Free article
Abstract
Huang et al. (2021) identified a mechanism acting through the arginine methyltransferase PRMT6 that stabilizes the interaction of RCC1 with chromatin, promoting cell proliferation and tumorigenicity. Targeting this mechanism might enhance the treatment of tumors such as glioblastoma.
Copyright © 2021 Elsevier Inc. All rights reserved.
Comment on
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PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.Mol Cell. 2021 Mar 18;81(6):1276-1291.e9. doi: 10.1016/j.molcel.2021.01.015. Epub 2021 Feb 3. Mol Cell. 2021. PMID: 33539787 Free PMC article.
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