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. 2021 Apr:193:57-60.
doi: 10.1016/j.puhe.2021.01.011. Epub 2021 Jan 29.

Vaccines for COVID-19: learning from ten phase II trials to inform clinical and public health vaccination programmes

Sunil S Bhopal  1 , Bayanne Olabi  2 , Raj Bhopal  3
Affiliations

Vaccines for COVID-19: learning from ten phase II trials to inform clinical and public health vaccination programmes

Sunil S Bhopal et al. Public Health. 2021 Apr.

Abstract

Public health professionals and clinicians, in many countries, are immersed in the ongoing and upcoming vaccination programmes for COVID-19. Published information from vaccine trials is complex. There are important and helpful insights about the nature of the available and forthcoming vaccines, immune responses and side-effects from phase II trials. We have systematically summarised information from 10 such trials on the nature of the vaccines, exclusions from the trials, immunological effects and side-effects. Some important information within these trial reports is not available in the phase III trial articles, so a complete picture requires examination of phase II and phase III trials for each vaccine. We recommend our systematic approach for the examination of other upcoming COVID-19 vaccine phase II and III trials.

Keywords: COVID-19; Public health; SARS-CoV-2; Vaccination; Vaccine.

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References

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