Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 20;21(1):296.
doi: 10.1186/s12885-021-08023-z.

Trends in incidence and histological pattern of thyroid cancer in Ho Chi Minh City, Vietnam (1996-2015): a population-based study

Dung X Pham #  1   2 , Hien D Nguyen #  3   4 , An H T Phung #  3   4 , Tung D Bui #  5 , Thach S Tran #  6 , Bich N H Tran #  7 , Lan T Ho-Pham  8   9 , Tuan V Nguyen #  4   6   10   11
Affiliations

Trends in incidence and histological pattern of thyroid cancer in Ho Chi Minh City, Vietnam (1996-2015): a population-based study

Dung X Pham et al. BMC Cancer. .

Abstract

Background: The burden and trend of thyroid cancer in Vietnam have not been well documented. This study aimed to investigate the trends in incidence and histological pattern of thyroid cancer in Ho Chi Minh City from 1996 to 2015.

Methods: A population-based study retrieved data from the Ho Chi Minh City Cancer Registry during 1996-2015. Trends in the incidence of thyroid cancer were investigated based on age, gender, and histology for each 5-year period. Annual percentage change (APC) in incidence rates was estimated using Joinpoint regression analysis.

Results: In the study period, there were 5953 thyroid cancer cases (men-to-women ratio 1:4.5) newly diagnosed in Ho Chi Minh City with the mean age of 42.9 years (±14.9 years). The age-standardized incidence rate of thyroid cancer increased from 2.4 per 100,000 during 1996-2000 (95% confidence interval [95% CI]: 2.2-2.6) to 7.5 per 100,000 during 2011-2015 (95% CI: 7.3-7.9), corresponded to an overall APC of 8.7 (95% CI 7.6-9.9). The APC in men and women was 6.2 (95% CI: 4.2-8.2) and 9.2 (95% CI: 8.0-10.4), respectively. The incidence rate in the < 45 years age group was the highest diagnosed overall and increased significantly in both men (APC 11.0) and women (APC 10.1). Both genders shared similar distribution of subtype incidences, with papillary thyroid cancer constituted the most diagnosed (73.3% in men and 85.2% in women). The papillary thyroid cancer observed a markedly increase overall (APC of 10.7 (95% CI 9.3-12.0)).

Conclusions: There were appreciable increases in the age-standardized incidence rate of thyroid cancer in both genders, mainly contributed by the papillary subtype. The age of patients at diagnosis decreased gradually. The widespread utilization of advanced diagnostic techniques and healthcare accessibility improvement might play a potential role in these trends. Further investigations are needed to comprehend the risk factors and trends fully.

Keywords: Histological pattern; Incidence; Thyroid cancer; Trends; Vietnam.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Joinpoint regression curve of age-standardized incidence rates for thyroid cancer by gender in Ho Chi Minh City, 1996–2015
Fig. 2
Fig. 2
Joinpoint regression curve of age-standardized incidence rates for thyroid cancer by age group in Ho Chi Minh City, 1996–2015
Fig. 3
Fig. 3
Joinpoint regression curve of age-standardized incidence rates for papillary and non–papillary thyroid cancer in Ho Chi Minh City, 1996–2015
See this image and copyright information in PMC

References

    1. Rahbari R, Zhang L, Kebebew E. Thyroid cancer gender disparity. Future Oncol. 2010. - PMC - PubMed
    1. Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. J Am Med Assoc. 2006;295(18):2164–2167. doi: 10.1001/jama.295.18.2164. - DOI - PubMed
    1. David Schottenfeld JFF. Cancer epidemiology and prevention. 3. Oxford University Press; 2006. Thyroid cancer; p. 975.
    1. SEER. SEER cancer statistics review 1975–2006 national cancer institute. Cancer. 2008:1975–2006.
    1. Aschebrook-Kilfoy B, Ward MH, Sabra MM, Devesa SS. Thyroid cancer incidence patterns in the United States by histologic type, 1992-2006. Thyroid. 2011;21(2):125–134. doi: 10.1089/thy.2010.0021. - DOI - PMC - PubMed