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Review
. 2021 Aug;14(8):1644-1658.
doi: 10.1016/j.jcmg.2020.12.034. Epub 2021 Mar 17.

Computed Tomography-Derived 3D Modeling to Guide Sizing and Planning of Transcatheter Mitral Valve Interventions

Joris F Ooms  1 , Dee Dee Wang  2 , Ronak Rajani  3 , Simon Redwood  4 , Stephen H Little  5 , Michael L Chuang  6 , Jeffrey J Popma  6 , Gry Dahle  7 , Michael Pfeiffer  8 , Brinder Kanda  9 , Magali Minet  10 , Alexander Hirsch  11 , Ricardo P Budde  12 , Peter P De Jaegere  1 , Bernard Prendergast  3 , William O'Neill  2 , Nicolas M Van Mieghem  13
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Free article
Review

Computed Tomography-Derived 3D Modeling to Guide Sizing and Planning of Transcatheter Mitral Valve Interventions

Joris F Ooms et al. JACC Cardiovasc Imaging. 2021 Aug.
Free article

Abstract

A plethora of catheter-based strategies have been developed to treat mitral valve disease. Evolving 3-dimensional (3D) multidetector computed tomography (MDCT) technology can accurately reconstruct the mitral valve by means of 3-dimensional computational modeling (3DCM) to allow virtual implantation of catheter-based devices. 3D printing complements computational modeling and offers implanting physician teams the opportunity to evaluate devices in life-size replicas of patient-specific cardiac anatomy. MDCT-derived 3D computational and 3D-printed modeling provides unprecedented insights to facilitate hands-on procedural planning, device training, and retrospective procedural evaluation. This overview summarizes current concepts and provides insight into the application of MDCT-derived 3DCM and 3D printing for the planning of transcatheter mitral valve replacement and closure of paravalvular leaks. Additionally, future directions in the development of 3DCM will be discussed.

Keywords: 3D printing; computational modeling; mitral annular calcification; multidetector computed tomography; paravalvular leakage closure; transcatheter mitral valve replacement.

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Conflict of interest statement

Funding Support and Author Disclosures Dr. Wang has served as a consultant for Edwards Lifesciences, Boston Scientific, and Materialise. Dr. Redwood has served as a proctor and consultant for Edwards Lifesciences. Dr. Popma has received institutional grants from Medtronic, Boston Scientific, Edwards Lifesciences, and Abbott; and is a member of the Medical Advisory Board of Edwards Lifesciences. Dr. Little has served as a consultant for Abbot Cardiovascular and Medtronic; and has received a research grant from Siemens Health. Dr. Pfeiffer has served as a consultant for LivaNova Inc.; and has served as a speaker and proctor for Edwards Lifesciences and Abbott Cardiovascular. Dr. Dahle has served as a proctor for Abbot Cardiovascular. Mrs. Minet is a former employee of Materialise NV. Dr. O’Neill has served as a consultant for Boston Scientific. Dr. Van Mieghem has received research grant support from Abbott, Boston Scientific, Edwards Lifesciences, and Medtronic; and has served as a consultant for Abbott, Boston Scientific, Edwards Lifesciences, Medtronic, Pie Medical, and Materialise NV. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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